Results 91 to 100 of about 206,039 (334)

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Neural Fields for Highly Accelerated 2D Cine Phase Contrast MRI

Advanced Science, EarlyView.
ABSTRACT 2D cine phase contrast (CPC) MRI provides quantitative information on blood velocity and flow within the human vasculature. However, data acquisition is time‐consuming, motivating the reconstruction of the velocity field from undersampled measurements to reduce scan times. In this work, neural fields are proposed as a continuous spatiotemporal
Pablo Arratia, Martin J. Graves, Mary McLean, Carolin Pirkl, Carola‐Bibiane Schönlieb, Timo Schirmer, Florian Wiesinger, Matthias J. Ehrhardt   +7 more
wiley   +1 more source

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Search Strategies for Binary Feature Selection for a Naive Bayes Classifier [PDF]

, 2015
We compare in this paper several feature selection methods for the Naive Bayes Classifier (NBC) when the data under study are described by a large number of redundant binary indicators.
Cottrell, Marie, Lacaille, Jérôme, Rabenoro, Tsirizo, Rossi, Fabrice   +3 more
core   +3 more sources

Bayes and empirical Bayes: do they merge?

, 2012
Bayesian inference is attractive for its coherence and good frequentist properties. However, it is a common experience that eliciting a honest prior may be difficult and, in practice, people often take an {\em empirical Bayes} approach, plugging ...
Petrone, Sonia, Rousseau, Judith, Scricciolo, Catia   +2 more
core   +1 more source

The Dirichet-Multinomial model for multivariate randomized response data and small samples [PDF]

, 2012
In survey sampling the randomized response (RR) technique can be used to obtain truthful answers to sensitive questions. Although the individual answers are masked due to the RR technique, individual (sensitive) response rates can be estimated when ...
Avetisyan, M., Fox, G.J.A.
core   +1 more source

Spintronic Bayesian Hardware Driven by Stochastic Magnetic Domain Wall Dynamics

Advanced Science, EarlyView.
Magnetic Probabilistic Computing (MPC) utilizes intrinsic stochastic dynamics in domain walls to establish a hardware foundation for uncertainty‐aware artificial intelligence. Thermally driven domain‐wall fluctuations, voltage‐controlled magnetic anisotropy, and TMR readout enable fully electrical, tunable probabilistic inference.
Tianyi Wang, Bingqian Dai, Shijie Xu, Kin Wong, Yaochen Li, Yang Cheng, Qingyuan Shu, Haoran He, Puyang Huang, Hanshen Huang, Xixiang Zhang, Kang L. Wang   +11 more
wiley   +1 more source

The Inverted Exponentiated Gamma Distribution: A Heavy-Tailed Model with Upside Down Bathtub Shaped Hazard Rate

Statistica, 2019
In this article, we proposed and studied the inverted exponentiated gamma distribution (IEGD). IEGD is obtained by considering the inverse transformation of exponentiated gamma variate.
Abhimanyu Singh Yadav
doaj   +1 more source