Results 41 to 50 of about 8,843 (310)

Minimum Expected Loss Estimators of The Parameters of the Inverse Gaussian Distribution [PDF]

The Egyptian Statistical Journal, 1990
The parameters of the inverse Gaussian distribution are estimated by assuming a weighted squared-error loss function and minimizing the corresponding expected loss with respect to the posterior distribution.
Mohamed Mahmoud
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Bayesian Estimation of Stress Strength Reliability using Upper Record Values from Generalised Inverted Exponential Distribution [PDF]

International Journal of Mathematical, Engineering and Management Sciences, 2019
The paper develops Bayesian estimators and HPD intervals for the stress strength reliability of generalised inverted exponential distribution using upper record values.
Ritu Kumari, Kalpana K. Mahajan, Sangeeta Arora   +2 more
doaj   +1 more source

Inference on P(Y < X) Based on Ranked Set Sample for Generalized Pareto Distribution

Statistica, 2022
In this paper, the problem of estimation of R = P(Y < X) based on ranked set sampling, when (X,Y) follows generalised Pareto distribution (GPD) is considered. The maximum likelihood (ML) estimators and Bayes estimators of R are obtained.
Manoj Chacko, Shiny Mathew
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Bayesian Estimation of the Scale Parameter of the Marshall-Olkin Exponential Distribution under Progressively Type-II Censored Samples

Journal of Statistical Theory and Applications (JSTA), 2018
This paper studies the Bayes estimator, the maximum likelihood estimator and the approximate likelihood estimator of the scale parameter for the Marshall-Olkin exponential distribution under the progressive type-II censored sample.
Mukhtar M. Salah
doaj   +1 more source

On a design consistency property of hierarchical Bayes estimators in finite population samplings. [PDF]

, 2007
We obtain a limit of a hierarchical Bayes estimator of a finite population mean when the sample size is large. The limit is in the sense of ordinary calculus, where the sample observations are treated as fixed quantities. Our result suggests a simple way
Lahiri, P, Mukherjee, Kanchan
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A New Class of Bayes Minimax Estimators of the Mean Matrix of a Matrix Variate Normal Distribution

Mathematics
Bayes minimax estimation is important because it provides a robust approach to statistical estimation that considers the worst-case scenario while incorporating prior knowledge.
Shokofeh Zinodiny, Saralees Nadarajah
doaj   +1 more source