Results 121 to 130 of about 242,378 (342)

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

PM10 Impairs CD56dim NK Cell Cytotoxicity via FNBP1 Suppression to Exacerbate Rheumatoid Arthritis: Insights from Multimodal Multi‐Omics

Advanced Science, EarlyView.
This study, through multi‐omics approaches and animal models, revealed that air pollutant PM10 exacerbates the progression of rheumatoid arthritis (RA) by suppressing FNBP1 expression and impairing the cytotoxic function of CD56dim NK cells. The “PM10–FNBP1–NK cells” axis provided novel insights into the environmental pathogenesis of RA and suggested ...
Runhan Zhao, Qinyang Zhang, Yu Jiang, Dagang Tang, Xiao Qu, Jun Zhang, Yi Chen, Weixia Duan, Tao Li, Zhengwei Cai, Yanran Huang, Xiaoji Luo   +11 more
wiley   +1 more source

Bayes factor benefits for clinical psychology: review of child and adolescent evidence base. [PDF]

F1000Res, 2022
Bertelsen TB, Hoffart A, Rekdal SS, Zahl-Olsen R.   +3 more
europepmc   +1 more source

On the Relevance of the Bayesian Approach to Statistics [PDF]

In this essay, I argue about the relevance and the ultimate unity of the Bayesian approach in a neutral and agnostic manner. My main theme is that Bayesian data analysis is an effective tool for handling complex models, as proven by the increasing ...
Christian P. Robert
core   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Un análisis complementario del Factor Bayes en investigación cuantitativa biomédica

Revista Cubana de Investigaciones Biomédicas, 2020
Se evaluó la inferencia bayesiana mediante el analisis del factor Bayes para complementar la consistencia de las hipótesis nula y alterna de un estudio reciente de la revista.
Cristian Antony Ramos Vera
doaj  

ASSESSMENT OF RISK OF DEVELOPMENT OF THROMBO-HEMORRHAGIC COMPLICATIONS IN OBSTETRICS USING A PREDICTIVE COEFFICIENT KULBACK AND BAYES' THEOREM

Наука. Инновации. Технологии, 2022
A current study on developing a method of assessing the risk of thrombo-hemorrhagic complications in pregnant women with a prognostic factor Kulback and Bayes' theorem.
Tatiana Petrovna Bondar, Elena Olegovna Melikbekyan   +1 more
doaj  

Agreement test of P value versus Bayes factor for sample means comparison: analysis of articles from the Angle Orthodontist journal. [PDF]

BMC Med Res Methodol, 2023
Srimaneekarn N, Leelachaikul P, Thiradilok S, Manopatanakul S.   +3 more
europepmc   +1 more source

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Easy computation of the Bayes factor to fully quantify Occam's razor in least-squares fitting and to guide actions. [PDF]

Sci Rep, 2022
Dunstan DJ, Crowne J, Drew AJ.
europepmc   +1 more source