Results 151 to 160 of about 242,378 (342)

Simpson’s Paradox and the Bayes Factor

open access: yesJournal of the Royal Statistical Society Series B: Statistical Methodology, 1998
Summary A counter-example presented by Lindley to Aitkin’s posterior Bayes factor is examined. The paradoxical feature of the counter-example is found to be a simple case of Simpson’s paradox.
openaire   +2 more sources

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

open access: yesAdvanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang   +15 more
wiley   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

open access: yesAdvanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang   +14 more
wiley   +1 more source

Bayesian Analysis of Markov Switching Vector Error Correction Model [PDF]

open access: yes
This paper introduces a Bayesian approach to a Markov switching vector error correction model that allows for regime shifts in the intercept terms, the lag terms, the adjustment terms and the variance-covariance matrix.
Sugita, Katsuhiro
core  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

open access: yesAdvanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu   +11 more
wiley   +1 more source

Calibrated Bayes Factors Should Not Be Used: A Reply to Hoijtink, van Kooten, and Hulsker

open access: green, 2016
Richard D. Morey   +2 more
openalex   +1 more source

BFCS: Bayes Factors of Covariance Structures

open access: green, 2020
Ioan Gabriel Bucur   +2 more
openalex   +2 more sources

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