Results 81 to 90 of about 2,193,761 (259)
Frontiers in OncologyBackgroundImmune checkpoint inhibitors (ICIs) are the standard first-line care for advanced non-small cell lung cancer (NSCLC). However, optimal therapeutic choices for patients with brain metastases remain unclear due to a lack of direct comparisons. We
Jie Luo +8 more
doaj +1 more source
How recent history affects perception: the normative approach and its heuristic approximation.
PLoS Computational Biology, 2012 There is accumulating evidence that prior knowledge about expectations plays an important role in perception. The Bayesian framework is the standard computational approach to explain how prior knowledge about the distribution of expected stimuli is ...
Ofri Raviv +2 more
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bayesian: Bindings for Bayesian TidyModels
, 2022 Fit Bayesian models using 'brms'/'Stan' with 'parsnip'/'tidymodels' via 'bayesian' . 'tidymodels' is a collection of packages for machine learning; see Kuhn and Wickham (2020) ). The technical details of 'brms' and 'Stan' are described in Bürkner (2017) ,
Bürkner, Paul-Christian +1 more
core +1 more source
Perceived Time Shapes Physical Fatigue Accumulation and Its Neural Oscillatory Correlates
Advanced Science, EarlyView.Can a clock change the course of physical fatigue? By covertly manipulating the clock calibration during repeated isometric contractions, we showed that perceived time shapes fatigue accumulation and frontal oscillatory dynamics. While fatigue accumulation was only reduced when the clock was slowed down, frontal oscillatory dynamics followed perceived ...
Pierre‐Marie Matta +3 more
wiley +1 more source
Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields
Advanced Science, EarlyView.Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng +71 more
wiley +1 more source
Model averaging, optimal inference and habit formation
Frontiers in Human Neuroscience, 2014 Postulating that the brain performs approximate Bayesian inference generates principled and empirically testable models of neuronal function – the subject of much current interest in neuroscience and related disciplines.
Thomas H B FitzGerald +2 more
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Advanced Science, EarlyView.The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English +9 more
wiley +1 more source
Frontiers in Computational Neuroscience, 2013 We perceive our surrounding environment by using different sense organs. However, it is notclear how the brain estimate information from our surroundings from the multisensory stimuli itreceives.
Itsuki eYamashita +10 more
doaj +1 more source
Advanced Science, EarlyView.An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee +11 more
wiley +1 more source
Advanced Science, EarlyView.Using a novel, aptamer‐based biosensor, here we have performed 20‐s‐resolved, in situ measurements of plasma‐free tryptophan in the jugular veins of live rats (blue). This unprecedented time‐resolution provides insights into the regulation of tryptophan metabolism in live, intact animals.
Yuyang Wu +7 more
wiley +1 more source