Results 161 to 170 of about 2,020,572 (302)
"Bayesian Estimation and Particle Filter for Max-Stable Processes" [PDF]
Extreme values are often correlated over time, for example, in a financial time series, and these values carry various risks. Max-stable processes such as maxima of moving maxima (M3) processes have been recently considered in the literature to describe ...
Zhengjun Zhang +2 more
core
Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Advanced Science, EarlyView.Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer +9 more
wiley +1 more source
Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia
Advanced Science, EarlyView.Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li +8 more
wiley +1 more source
Advanced Science, EarlyView.Computational simulations of tumor evolution are increasingly used to infer the rules underlying cancer growth, with the goal of one day recommending tailored treatments. Here we show that the properties of lung cancer sequencing data are best replicated by a model which assumes that cells compete both to proliferate and survive. ABSTRACT Computational
Helena Coggan +5 more
wiley +1 more source
Journal of the Society of Naval Architects of Japan, 1985 Itagaki, Hiroshi +2 more
openaire +3 more sources
Bayesian Estimation of the Binomial Parameter in Adaptive Designs With Treatment Selection. [PDF]
Stat MedBunouf P, Boher JM.
europepmc +1 more source
Advanced Science, EarlyView.Highly overlapping fluorescent signals become distinguishable in photon‐limited living organisms via advanced imaging with intelligent reconstruction. The resulting in vivo hyperspectral imaging capability reveals nanoplastic uptake and circulation in live zebrafish, providing a new approach for studying complex biological and environmental processes ...
Renjian Li +11 more
wiley +1 more source
Financial Risk Management with Bayesian Estimation of GARCH Models: Theory and Applications
, 2008 This book presents in detail methodologies for the Bayesian estimation of single-regime and regime-switching GARCH models. These models are widespread and essential tools in financial econometrics and have, until recently, mainly been estimated using the
Ardia, David
core
Bayesian Estimation of Vancomycin Exposure and Population Pharmacokinetics in Obese Patients. [PDF]
Antibiotics (Basel)Chun HJ +6 more
europepmc +1 more source
CoSP: Reconfigurable Metamaterial Inverse Design via Contrastive Pretrained Large Language Model
Advanced Science, EarlyView.In this work, CoSP (contrastive multi‐state pretrain), an intelligent inverse design method for reconfigurable metamaterials based on a contrastive pretrained large language model, is proposed. Numerical experiments demonstrate that CoSP can design reconfigurable metamaterial structures for multi‐state, multi‐band optical responses, showing great ...
Shujie Yang +4 more
wiley +1 more source