Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation
Advanced Science, EarlyView.Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang +7 more
wiley +1 more source
On the J-test for nonnested hypotheses and Bayesian extension [PDF]
Davidson and MacKinnon’s J-test was developed to test non-nested model specification. In empirical applications, however, when the alternate specifications fit the data well the J test may fail to distinguish between the true and false models: the J test
Krieg, John, Rao, Surekha, Ghali, Moheb
core
Bayesian Estimation of Marginal Quantiles with Missing Data in a Multivariate Regression Framework. [PDF]
Entropy (Basel)Morán-Vásquez RA +2 more
europepmc +1 more source
Advanced Science, EarlyView.TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao +8 more
wiley +1 more source
Bayesian Estimation Improves Prediction of Outcomes After Epilepsy Surgery. [PDF]
Ann Clin Transl NeurolDickey AS +4 more
europepmc +1 more source
A Robotic Testing Platform for Pipelined Discovery of Resilient Dielectric Elastomer Actuators
Advanced Science, EarlyView.This work introduces a robotic testing platform enabling high‐throughput, multi‐parameter lifetime mapping of linear dielectric elastomer actuators (DEAs). By integrating programmable high‐voltage control and automated electromechanical measurements, the system identifies material and operating conditions that double actuator lifetime.
Ang (Leo) Li +10 more
wiley +1 more source
Bayesian estimation yields anti-Weber variability. [PDF]
PNAS NexusPrat-Carrabin A, Gershman SJ.
europepmc +1 more source
Machine Learning of Temperature‐Dependent Chemical Kinetics Using Parallel Droplet Microreactors
Advanced Science, EarlyView.An integrated droplet microfluidics and machine learning framework enables high‐throughput characterization of temperature‐dependent reaction kinetics. Time‐resolved measurements from thousands of droplets train Neural ODE models that accurately predict nonlinear reaction dynamics across diverse thermal environments, bridging large‐scale ...
Mamoru Saita, Yutaka Hori
wiley +1 more source
Bayesian estimation of covariate assisted principal regression for brain functional connectivity. [PDF]
BiostatisticsPark HG.
europepmc +1 more source
Perceived Time Shapes Physical Fatigue Accumulation and Its Neural Oscillatory Correlates
Advanced Science, EarlyView.Can a clock change the course of physical fatigue? By covertly manipulating the clock calibration during repeated isometric contractions, we showed that perceived time shapes fatigue accumulation and frontal oscillatory dynamics. While fatigue accumulation was only reduced when the clock was slowed down, frontal oscillatory dynamics followed perceived ...
Pierre‐Marie Matta +3 more
wiley +1 more source