Results 41 to 50 of about 115,501 (297)
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
On identifying the optimal number of population clusters via the deviance information criterion. [PDF]
PLoS ONE, 2011 Inferring population structure using bayesian clustering programs often requires a priori specification of the number of subpopulations, K, from which the sample has been drawn. Here, we explore the utility of a common bayesian model selection criterion,
Hong Gao +2 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Statistical Analysis of Displacement and Length Relation for Normal Faults in the Barents Sea
Geosciences, 2018 This paper is devoted to the statistical analysis of dependence between fault length (L) and displacement (D). The main purpose of this work is to study the scaling relations between fault length and displacement using a database that includes datasets ...
Dmitriy Kolyukhin +4 more
doaj +1 more source
Modeling and analysis of recovery time for the COVID-19 patients: a Bayesian approach
Arab Journal of Basic and Applied Sciences, 2023 The ongoing pandemic of COVID-19 has changed every aspect of life. Most of the people who become a victim of COVID-19 experience mild to moderate symptoms, but some people may become seriously ill.
Kahkashan Ateeq +2 more
doaj +1 more source
Model comparison (Bayesian Information Criterion (BIC)).
, 2021 Model comparison (Bayesian Information Criterion (BIC)). Compared to AIC, BIC model comparison penalizes model complexity more heavily. MML denotes “Maximum Marginal Likelihood,” MMP denotes “Maximum Marginal Posterior,” MJP denotes “Maximum Joint ...
Wei Ji Ma (9707948) +1 more
core +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source