Results 41 to 50 of about 108,936 (256)

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Multiple Regression Model Selection by Information Criteria [PDF]

open access: yesالمجلة العراقية للعلوم الاحصائية, 2009
In this paper, I considered the problem of selection a model from a collection of candidate models specified by multiple linear regression model. Two criteria are used and compared, they are Akaike information criterion ( ) and Bayesian information ...
Zakaria Y. AL-Jammal
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Previsão da temperatura média mensal de Uberlândia, MG, com modelos de séries temporais Forecast of monthly mean temperatures in Uberlândia, Minas Gerais, Brazil using time series models

open access: yesRevista Brasileira de Engenharia Agrícola e Ambiental, 2008
Modelos de séries temporais têm sido amplamente usados no estudo de variáveis climatológicas, como temperatura e precipitação. Diversos são os objetivos traçados neste trabalho a fim de se analisar a série de temperatura média mensal da cidade de ...
Maria I. S. Silva   +2 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

open access: yesAging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss   +12 more
wiley   +1 more source

A procedure for tidal analysis with a Bayesian information criterion [PDF]

open access: yesGeophysical Journal International, 2007
SUMMARY A computer algorithm for tidal analysis is developed, based on a Bayesian method proposed by Ishiguro ef af. (1983). The basic assumption of the method is smoothness of the drift. This assumption is represented in the form of prior probability in the Bayesian model.
Y. Tamura, T. Sato, M. Ooe, M. Ishiguro
openaire   +1 more source

Efficacy of Inebilizumab in N‐MOmentum Trial Participants With or Without Prior Immunosuppressants

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This post hoc analysis examined the impact of prior immunosuppressants on the long‐term efficacy and safety of inebilizumab, a cluster of differentiation 19+ B‐cell–depleting monoclonal antibody, in participants with aquaporin‐4–seropositive neuromyelitis optica spectrum disorder from the N‐MOmentum trial (NTC02200770).
Bruce A. C. Cree   +9 more
wiley   +1 more source

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