Results 51 to 60 of about 11,544,586 (297)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Parameter estimation of exponentiated Rayleigh distribution under different loss functions [PDF]

open access: yesMemoirs of the Scientific Sections of the Romanian Academy, 2021
In this paper, exponentiated Rayleigh distribution is considered for Bayesian analysis. The expressions for Bayes estimators of the parameter have been derived under squared error, precautionary, entropy, K-loss, and Al-Bayyati’s loss functions by using ...
Arun Kumar Rao, Himanshu Pandey
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Bayesian Inference and Compressed Sensing [PDF]

open access: yes, 2017
This chapter provides the use of Bayesian inference in compressive sensing (CS), a method in signal processing. Among the recovery methods used in CS literature, the convex relaxation methods are reformulated again using the Bayesian framework and this ...
Tesfamicael, Solomon Abedom
core   +1 more source

Probabilistic characterization of underground stratigraphy and its uncertainty based on cone penetration test

open access: yesYantu gongcheng xuebao, 2018
A Bayesian framework is developed to probabilistically identify the underground stratigraphy based on Ic data. The proposed Bayesian framework identifies the most probable soil layer boundaries with the consideration of spatial variability of Ic and ...
CAO Zi-jun 1, ZHENG Shuo 1, LI Dian-qing 1, AU Sui-kiu 2
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Some results of classification problem by Bayesian method and application in credit operation

open access: yesStatistical Theory and Related Fields, 2018
This study proposes some results in classifying by Bayesian method. There are upper and lower bounds of the Bayes error as well as its determination in case of one dimension and multi-dimensions.
Tai Vovan
doaj   +1 more source

Independence and Bayesian updating methods [PDF]

open access: yesArtificial Intelligence, 1986
Appears in Proceedings of the First Conference on Uncertainty in Artificial Intelligence (UAI1985)
openaire   +6 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

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