Results 61 to 70 of about 12,151,236 (300)

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Bayesian factorial linear Gaussian state-space models for biosignal decomposition [PDF]

, 2007
We discuss a method to extract independent dynamical systems underlying a single or multiple channels of observation. In particular, we search for one-dimensional subsignals to aid the interpretability of the decomposition. The method uses an approximate
Chiappa, S, Barber, D
core  

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Linear Bayesian Methods

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1969
Summary A method of linear prediction is proposed, which follows the Bayesian scheme in combining prior and present information, but which uses only the first two moments of the distribution of parameters and observations, rather than the complete probability model required of Bayesian techniques.
openaire   +2 more sources

Using stacking to average bayesian predictive distributions (with discussion) [PDF]

, 2018
Bayesian model averaging is flawed in the M-open setting in which the true data-generating process is not one of the candidate models being fit. We take the idea of stacking from the point estimation literature and generalize to the combination of ...
Grunwald, Peter, Castro-Camilo, Daniela, Li, Meng, Shin, Minsuk, Grushka-Cockayne, Yael, Gelman, Andrew, Lichtendahl, Kenneth C., Iacopini, Matteo, Dawid, A. Philip, van Dijk, Herman K., Lichtendahl, Kenneth C, Yao, Yuling, Zhou, Tianjian, Winkler, Robert L, Aastveit, Knut Are, Dawid, A Philip, Yoo, William Weimin, Pericchi, Luis, Clarke, Bertrand, Bakka, Haakon C, Freni-Sterrantino, Anna, Franck, Christopher T., Hoogerheide, Lennart, Tonellato, Stefano, Winkler, Robert L., Simpson, Daniel, Ferreira, Marco A. R., Franco-Villoria, Maria, Belitser, Eduard, Bakka, Haakon C., van Dijk, Herman K, Ferreira, Marco AR, de Heide, Rianne, Nurushev, Nurzhan, Jose, Victor Richmond R., Vehtari, Aki, Clyde, Merlise, McAlinn, Kenichiro, West, Mike, Rue, Havard, Huser, Raphael, Opitz, Thomas, Jose, Victor Richmond R, Franck, Christopher T   +43 more
core   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

Where Is the clean air? A bayesian decision framework for personalised cyclist route selection using R-INLA

, 2021
This is the final version. Available on open access from the International Society for Bayesian Analysis via the DOI in this recordExposure to air pollution in the form of fine particulate matter (PM2.5) is known to cause diseases and cancers ...
Morawska, Lidia, Jayaratne, Rohan, Mengersen, Kerrie L., Dawkins, Laura C., Shaddick, Gavin, Williamson, Daniel B.   +5 more
core   +1 more source

Comparative Analysis of Choroid Plexus Volume Between MOG Antibody Associated Disease and Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Choroid plexus volume (CPV) has been proposed as a neuro‐immunological marker of multiple sclerosis (MS), but its relevance in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) remains uncertain. We analyzed CPV in 43 individuals with MOGAD, 48 with MS, and 44 healthy controls using a Bayesian Gaussian mixture modeling ...
Jae‐Won Hyun, Shaun G. Hong, Na Young Park, Su‐Hyun Kim, Ho Jin Kim   +4 more
wiley   +1 more source

Subjective Cognitive Concerns and Cognitive Trajectories in Parkinson's Disease: Biomarker Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the relationship of subjective cognitive concerns (SCC) with biomarkers of Alzheimer's disease (AD), neurodegeneration, and Parkinson's disease (PD) and domain‐specific cognitive trajectories among cognitively unimpaired persons with de novo PD. Method Cognitively unimpaired participants with SCC (n = 294) and without SCC (
Francesca V. Lopez, Fareshte Erani, Katherine J. Bangen, David G. Coughlin, Douglas Galasko, Kelsey R. Thomas   +5 more
wiley   +1 more source

Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Conventional MRI cannot resolve the coexisting pathological processes within multiple sclerosis tissue. Diffusion Basis Spectrum Imaging decomposes the diffusion signal into fiber, cell, and hindered ratios indexing axonal integrity, cellularity, and extracellular space, respectively.
Apisit Kaewsanit, Aime Luna, Bradley Judge, Nicole Shelley, Karl Friedrichsen, Jayashree Rajamanickam, Zhude Tu, Yong Wang, Tammie L. S. Benzinger, Qing Wang, Matthew R. Brier   +10 more
wiley   +1 more source