Results 51 to 60 of about 15,712,923 (297)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Neural basis of somatosensory target detection independent of uncertainty, relevance, and reports
eLife, 2019 Research on somatosensory awareness has yielded highly diverse findings with putative neural correlates ranging from activity within somatosensory cortex to activation of widely distributed frontoparietal networks. Divergent results from previous studies
Pia Schröder +2 more
doaj +1 more source
R Package OBsMD for Follow-Up Designs in an Objective Bayesian Framework
Journal of Statistical Software, 2020 Fractional factorial experiments often produce ambiguous results due to confounding among the factors; as a consequence more than one model is consistent with the data. Thus, the practical problem is how to choose additional runs in order to discriminate
Laura Deldossi, Marta Nai Ruscone
doaj +1 more source
BAYESIAN MODEL SELECTION AND FORECASTING IN NONCAUSAL AUTOREGRESSIVE MODELS [PDF]
Journal of Applied Econometrics, 2009 SUMMARYIn this paper, we propose a Bayesian estimation and forecasting procedure for noncausal autoregressive (AR) models. Specifically, we derive the joint posterior density of the past and future errors and the parameters, yielding predictive densities as a by‐product.
Luoto Jani, Lanne Markku, Luoma Arto
openaire +3 more sources
Efficient utility-based clustering over high dimensional partition spaces [PDF]
, 2009 Because of the huge number of partitions of even a moderately sized dataset, even when Bayes factors have a closed form, in model-based clustering a comprehensive search for the highest scoring (MAP) partition is usually impossible.
Smith, JQ +9 more
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
A Bayesian Approach to the Vertical Structure of the Disk of the Milky Way
The Open Journal of Astrophysics, 2020 This work investigates the vertical profile of the stars in the disk of the Milky Way. The models investigated are of the form sech2/n(nz/(2H)) where, setting α = 2/n, the three functions of the sequence α= 0, 1, 2 correspond to exponential, sech, and ...
Phillip S. Dobbie , Stephen J. Warren
doaj +1 more source
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source