Results 61 to 70 of about 15,911,760 (295)
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Bayesian Geoadditive Sample Selection Models
Journal of the Royal Statistical Society Series C: Applied Statistics, 2010 SummarySample selection models attempt to correct for non-randomly selected data in a two-model hierarchy where, on the first level, a binary selection equation determines whether a particular observation will be available for the second level, i.e. in the outcome equation.
Wiesenfarth, Manuel, Kneib, Thomas
openaire +2 more sources
On the effect of prior assumptions in Bayesian model averaging with applications to growth regresssion [PDF]
, 2007 We consider the problem of variable selection in linear regression models. Bayesian model averaging has become an important tool in empirical settings with large numbers of potential regressor and relatively limited numbers of observations.
Eduardo Ley +4 more
core +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
BMC Medical Research Methodology, 2010 Background Automatic variable selection methods are usually discouraged in medical research although we believe they might be valuable for studies where subject matter knowledge is limited.
Steineck Gunnar +3 more
doaj +1 more source
Yantu gongcheng xuebao, 2023 In order to establish an optimal model for estimating the uniaxial compressive strength (UCS) of rocks as well as its reasonable estimation, a fully Bayesian Gaussian process regression method (fB-GPR) is proposed by combining the Gaussian process ...
SONG Chao , ZHAO Tengyuan , XU Ling
doaj +1 more source
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Bayesian Analysis of Sample Selection and Endogenous Switching Regression Models with Random Coefficients Via MCMC Methods [PDF]
, 2002 This paper develops a Bayesian method for estimating and testing the parameters of the endogenous switching regression model and sample selection models.
Odejar, M. A. E.
core +1 more source