Results 211 to 220 of about 2,535,602 (380)

Association Between Vascular NOTCH3 Aggregation and Disease Severity in a CADASIL Cohort – Implications for NOTCH3 Variant‐Specific Disease Prediction

open access: yesAnnals of Neurology, EarlyView.
Objective Vascular NOTCH3 protein ectodomain aggregation is a pathological hallmark of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a monogenic small vessel disease typically caused by cysteine‐altering variants in NOTCH3.
Minne N. Cerfontaine   +10 more
wiley   +1 more source

Quantitative Analysis of Fluorescent Sensor Arrays

open access: yesAnalysis &Sensing, Accepted Article.
Fluorescent sensor arrays address the limitations of a single sensor by leveraging multiple sensing elements to generate unique response patterns for each of the analyte of interest. This approach has emerged as a powerful tool for identifying and analysing intricate chemical and biological environments using various multivariate analytical tools such ...
Karandeep Grover   +3 more
wiley   +1 more source

Sloppiness Consistency in Biomechanical Models and Its Inspired Dual‐Space Model Optimization

open access: yesAdvanced Physics Research, EarlyView.
This study addresses the challenge of balancing complexity, accuracy, and parameter identifiability in soft tissue constitutive modeling. By leveraging information geometry and sensitivity analysis, the sloppiness inherent in biomechanical models is revealed, and a model reduction framework is proposed. This approach optimizes parameter identifiability
Jiabao Tang   +3 more
wiley   +1 more source

Regional Shopping Objectives in British Grocery Retail Transactions Using Segmented Topic Models

open access: yesApplied Stochastic Models in Business and Industry, EarlyView.
ABSTRACT Understanding the customer behaviours behind transactional data has high commercial value in the grocery retail industry. Customers generate millions of transactions every day, choosing and buying products to satisfy specific shopping needs.
Mariflor Vega Carrasco   +4 more
wiley   +1 more source

Altered Patterns of Dynamic Functional Connectivity Underpin Reduced Expressions of Social–Emotional Reciprocity in Autistic Adults

open access: yesAutism Research, Volume 18, Issue 4, Page 725-740, April 2025.
ABSTRACT To identify the neurocognitive mechanisms underpinning the social difficulties that characterize autism, we performed functional magnetic resonance imaging on pairs of autistic and non‐autistic adults simultaneously whilst they interacted with one another on the iterated Ultimatum Game (iUG)—an interactive task that emulates the reciprocal ...
Kristína Czekóová   +8 more
wiley   +1 more source

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