Results 1 to 10 of about 3,528 (147)

Immunogenicity induced by the use of alternative vaccine platforms to deal with vaccine shortages in a low- to middle-income country: Results of two randomized clinical trials

The Lancet Regional Health. Americas, 2022
Summary: Background: Shortages of component two of Sputnik V vaccine (rAd5) are delaying the possibility of achieving full immunisation. The immunogenic response associated with the use of alternative schemes to complete the scheme was not explored ...
Alejandro Macchia, Daniel Ferrante, María Belén Bouzas, Patricia Angeleri, Cristián Biscayart, Jorge Geffner, Lilia Mammana, Inés Zapiola, Eduardo Luis López, Angela Gentile, Augusto Varese, Ignacio Mazzitelli, Facundo Di Diego García, Deborah Sharff, Verónica Lucconi, Paula Sujansky, Javier Mariani, Fernán González Bernaldo de Quirós   +17 more
doaj   +1 more source

Effectiveness of COVID‐19 Vaccination in Reducing Severity Among SARS‐CoV‐2 Infected Patients: A Prospective Study From Iraq

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background Coronavirus disease 2019 (COVID‐19) is a lethal global pandemic that originated in Wuhan, China at the end of 2019. As with other viral infectious diseases, the introduction of an effective vaccine is crucial for stopping the spread of the pandemic. In Iraq the COVID‐19 vaccination campaign started on March 2, 2021.
Ahmed Hakim Al‐Obaidi, Marwan Majeed Ibrahim, Abdul Hameed Abdul Majeed Al‐Qaseer   +2 more
wiley   +1 more source

Cervical longitudinally extensive myelitis after vaccination with inactivated virus-based COVID-19 vaccine

Radiology Case Reports, 2022
Myelitis, including longitudinally extensive transverse myelitis (LTEM), is reported in more than forty patients after coronavirus disease 2019 (COVID-19).
Mahsa Sepahvand, MD, Narges Yazdi, MD, Mohammad Rohani, MD, Maziar Emamikhah, MD   +3 more
doaj   +1 more source

Pre‐Existing Th1 Immunity Outperforms Age in Predicting Antibody Responses to SARS‐CoV‐2 Inactivated Vaccines

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Challenging the focus on age, this study finds pre‐existing T helper 1 cells are the key biomarker for predicting antibody response to SARS‐CoV‐2 inactivated vaccines. In both mice and humans, high responders exhibited elevated baseline T helper 1 cells, which correlated with robust humoral immunity, offering crucial guidance for improving vaccine ...
Chanyuan Ye, Xiaoli Zhang, Lingfeng Qiu, Jia Ji, Jueqing Gu, Hongyu Jia, Yingfeng Lu, Jiyang Chen, Zelu Meng, Jiangshan Lian, Hangping Yao, Xun Zeng, Yida Yang   +12 more
wiley   +1 more source

Kinetics of IgA Subtypes and Cytokines in Respiratory Secretions Following Immunization With COVID‐19 Mucosal Vaccine

Journal of Medical Virology, Volume 97, Issue 10, October 2025.
ABSTRACT The COVID‐19 pandemic highlights the need for mucosal vaccines inducing respiratory secretory IgA (sIgA), as traditional intramuscular vaccines primarily elicit systemic IgG with limited mucosal protection. This study systematically compared mucosal immune responses induced by two authorized COVID‐19 mucosal vaccines: an orally aerosolized ...
Weixin Chen, Juan Li, Shuang Bai, Ao Zhang, Qun Zheng, Junnan Zhang, Wenwen Lan, Yihan Zhang, Wei Yao, Wei Zhao, Jiang Wu   +10 more
wiley   +1 more source

Vaccine Induced Immune Thrombotic Thrombocytopenia After Sinopharm Vaccination: A Systematic Review of Case Reports

Clinical Case Reports, Volume 13, Issue 9, September 2025.
ABSTRACT Vaccine‐induced thrombotic thrombocytopenia (VITT) has been linked to vector‐based vaccines, but only four cases following whole‐virus vaccines (Sinopharm) have been reported, as far as we are aware. This systematic review aimed to compile the clinical and laboratory results of VITT development after Sinopharm vaccination.
Shafi Rehman, Mahnoor Sukaina, Hasibullah Aminpoor, Sissmol Davis, Amna Bint I Munir, Hasiba Karimi   +5 more
wiley   +1 more source

Humoral Immune Response to Breakthrough Infection With SARS‐CoV‐2 Delta and Omicron Variants

iLABMED, Volume 3, Issue 3, Page 266-274, September 2025.
Patients with breakthrough infections of the Omicron variant exhibited significantly higher levels of neutralizing antibodies and IgG than those infected with the Delta variant. By contrast, Delta‐infected patients showed higher levels of IgM and IgA than Omicron‐infected patients.
Xihong Zhang, Chungen Qian, Huixia Gao, Li Yang, Yuling Wang, Ying Huang, Xin Zhang, Aidong Feng, Calvin Q. Pan, Yuzhu Shi, Ying Chen, Bangning Cheng, Erhei Dai   +12 more
wiley   +1 more source

Evaluation of the Humoral Immune Response of a Heterologous Vaccination between BBIBP-CorV and BNT162b2 with a Temporal Separation of 7 Months, in Peruvian Healthcare Workers with and without a History of SARS-CoV-2 Infection

Vaccines, 2022
Information on the effects of a heterologous booster in adult patients first vaccinated with the BBIBP-CorV vaccine is limited. This prospective cohort study evaluated the humoral response of 152 healthcare workers (HCWs) from a private laboratory in ...
Miguel Hueda-Zavaleta, Juan C. Gómez de la Torre, José Alonso Cáceres-Del Aguila, Cecilia Muro-Rojo, Nathalia De La Cruz-Escurra, Daniella Arenas Siles, Diana Minchón-Vizconde, Cesar Copaja-Corzo, Fabrizzio Bardales-Silva, Vicente A. Benites-Zapata, Alfonso J. Rodriguez-Morales   +10 more
doaj   +1 more source

COVID‐19 Vaccine Hesitancy, Self‐Reported Adverse Events, and Determinants Among Ethiopian Healthcare Professionals During COVID‐19 Pandemic

Public Health Challenges, Volume 4, Issue 3, September 2025.
Among Ethiopian HCPs, 45.6% hesitated to take the first COVID‐19 vaccine dose due to safety and efficacy concerns. Addressing these through transparent communication and religious engagement is crucial to boost vaccine uptake. ABSTRACT This nationwide cross‐sectional online survey aimed to assess coronavirus disease 2019 (COVID‐19) vaccine hesitancy ...
Alfoalem Araba Abiye, Sisay Endale, Zenebe Negash, Shemsu Umer Hussen, Dawit Teshome Gebregeorgise, Melaku Tileku Tamiru, Dessale Abate Beyene, Hana Shafi Amde, Amanuel Yishak Negash   +8 more
wiley   +1 more source

Revolution of AAV in Drug Discovery: From Delivery System to Clinical Application

Journal of Medical Virology, Volume 97, Issue 6, June 2025.
ABSTRACT Adeno‐associated virus (AAV) is a non‐enveloped DNA virus infecting a wide variety of species, tissues, and cell types, which is recognized as a safe and effective method for delivering therapeutic transgenes. AAV vector is the most popular viral gene delivery system in clinical delivery systems with unique and multiple advantages, such as ...
Ling Yin, Hongliang He, Hongliang Zhang, Yuhua Shang, Chengbo Fu, Songquan Wu, Tengchuan Jin   +6 more
wiley   +1 more source