Results 21 to 30 of about 405,410 (243)

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Three Key Problems in Classroom Language Education Research

BC TEAL Journal, 2023
This opinion essay begins by describing the problematic difference between “doing-research-on” and “doing-research-with,” particularly in relation to classroom-based research on foreign/English language teaching and learning.
Andy
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

An interplay between genes SLCO1B1, NR2F2, JMJD1C and obesity in developing breast cancer

Акушерство, гинекология и репродукция
Aim: to evaluate a role of polymorphic variants rs4149056 SLCO1B1, rs8023580 NR2R2 and rs7910927 JMJD1C in developing obesity-related female breast cancer (BC).Materials and Methods.
K. N. Pasenov, I. V. Ponomarenko, M. I. Churnosov   +2 more
doaj   +1 more source

LncRNA MIAT Services as a Noninvasive Biomarker for Diagnosis and Correlated with Immune Infiltrates in Breast Cancer

International Journal of Women's Health, 2021
Ting Ye,1,* Jia Feng,1,* Meng Cui,2 Jia Yang,2 Xue Wan,1 Dan Xie,1 Jinbo Liu1 1Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 2Department of ...
Ye T, Feng J, Cui M, Yang J, Wan X, Xie D, Liu J   +6 more
doaj  

Student Volunteer Motivations in a Student Support Centre for English for Academic Purposes Students

BC TEAL Journal, 2021
The findings presented in this paper look at the motivations of volunteers who supported English for Academic Purposes students at a self-access Language Learning Centre at a university in Canada.
Joe Dobson, Hilda Freimuth, Ishka Rodriques   +2 more
doaj   +1 more source

Lifetimes of $\Xi_{bc}^+$ and $\Xi_{bc}^0$ baryons [PDF]

The European Physical Journal C, 2000
Estimates of lifetimes and partial branching ratios for the baryons $ _{bc}^{+}$ and $ _{bc}^{0}$ are presented using the inverse heavy quark mass expansion technique carried out in the Operator Product Expansion approach. We take into account both the perturbative QCD corrections to the spectator contributions and, depending on the quark contents of
Kiselev, V. V., Likhoded, A. K., Onishchenko, A. I.   +2 more
openaire   +2 more sources