Results 61 to 70 of about 1,137 (152)

Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis

Arthritis Research & Therapy, 2021
Background Exercise training, including high-intensity interval training (HIIT), improves rheumatoid arthritis (RA) inflammatory disease activity via unclear mechanisms.
Brian J. Andonian, Andrew Johannemann, Monica J. Hubal, David M. Pober, Alec Koss, William E. Kraus, David B. Bartlett, Kim M. Huffman   +7 more
doaj   +1 more source

Multiomics analyses of Jining Grey goat and Boer goat reveal genomic regions associated with fatty acid and amino acid metabolism and muscle development [PDF]

Animal Bioscience
Objective Jining Grey goat is a local Chinese goat breed that is well known for its high fertility and excellent meat quality but shows low meat production performance.
Zhaohua Liu, Xiuwen Tan, Qing Jin, Wangtao Zhan, Gang Liu, Xukui Cui, Jianying Wang, Xianfeng Meng, Rongsheng Zhu, Ke Wang   +9 more
doaj   +1 more source

Phenotypic Heterogeneity in Genetic and Acquired Pediatric Cerebellar Disorders

Movement Disorders, Volume 40, Issue 9, Page 1851-1862, September 2025.
Abstract Background The genetic landscape of pediatric cerebellar disorders (PCDs) in Finland is undefined. Objectives The objective was to define epidemiological, clinical, neuroradiological, and genetic characteristics of PCDs in Northern Finland.
Katariina Granath, Sanna Huhtaniska, Juulia Ellonen, Tytti Pokka, Salla M. Kangas, Jukka Moilanen, Heli Helander, Hanna Kallankari, Jonna Komulainen‐Ebrahim, Päivi Vieira, Elisa Rahikkala, Renzo Guerrini, Minna Honkila, Terhi S. Ruuska, Reetta Hinttala, Maria Suo‐Palosaari, Jussi‐Pekka Tolonen, Johanna Uusimaa   +17 more
wiley   +1 more source

Application of droplet digital PCR in the analysis of genome integration and organization of the transgene in BAC transgenic mice [PDF]

, 2018
Transgenic (Tg) mice containing bacterial artificial chromosome (BAC) DNA are widely used for gene expression analysis and gene therapy models because BAC transgenes provide gene expression at physiological levels with the same developmental timing as ...
Tatsuya Kishino, Hirano, Shiori, Kishino, Tatsuya, Nakagaki, Ayumi, Ayumi Nakagaki, Anami, Takeru, Asuka Urakawa, Urakawa, Asuka, Shiori Hirano, Takeru Anami   +9 more
core   +1 more source

Genome-Wide Assessment of Runs of Homozygosity in Chinese Wagyu Beef Cattle

Animals, 2020
Runs of homozygosity (ROH) are continuous homozygous regions that generally exist in the DNA sequence of diploid organisms. Identifications of ROH leading to reduction in performance can provide valuable insight into the genetic architecture of complex ...
Guoyao Zhao, Tianliu Zhang, Yuqiang Liu, Zezhao Wang, Lei Xu, Bo Zhu, Xue Gao, Lupei Zhang, Huijiang Gao, George E. Liu, Junya Li, Lingyang Xu   +11 more
doaj   +1 more source

Mitochondrial complex I deficiency induces Alzheimer's disease–like signatures that are reversible by targeted therapy

Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.
Abstract INTRODUCTION Mitochondrial dysfunction is implicated in Alzheimer's disease (AD), but whether it drives AD‐associated changes is unclear. We assessed transcriptomic alterations in the brains of Ndufs4−/− mice, a model of mitochondrial complex I (mtCI) deficiency, and evaluated the therapeutic effects of the neuroprotective mtCI inhibitor CP2 ...
Huanyao Gao, Kate Jensen, Jarred Nesbitt, Mark Ostroot, Gregory A. Cary, Jesse Wiley, Sergey Trushin, Jens O. Watzlawik, Wolfdieter Springer, Alexander Galkin, Priyanka Baloni, Cory Funk, Eugenia Trushina   +12 more
wiley   +1 more source

Análise do genótipo e fenótipo em pacientes brasileiros com hiperfenilalaninemias e doença da urina do xarope do bordo [PDF]

, 2021
Introdução: As Aminoacidopatias são um grupo de Erros Inatos do Metabolismo onde defeitos em enzimas do metabolismo de aminoácidos causam o acúmulo de substratos metabólicos, que podem ser extremamente neurotóxicos.
Tresbach, Rafael Hencke
core   +1 more source

Gut Microbiome and Metabolome Changes in Chronic Low Back Pain Patients With Vertebral Bone Marrow Lesions

JOR SPINE, Volume 8, Issue 1, March 2025.
This study explores the link between the gut microbiome, serum metabolome, and fatty replacement (FR) in chronic low back pain (LBP) patients. Findings reveal that dysbiosis in the gut microbiome and altered branched‐chain amino acid (BCAA) levels contribute to FR through the SIRT4 pathway, suggesting potential therapeutic strategies targeting gut ...
Wentian Li, Ji Tu, Jinjian Zheng, Abhirup Das, Qi Yan, Xiaotao Jiang, Wenyuan Ding, Xupeng Bai, Kaitao Lai, Sidong Yang, Cao Yang, Jun Zou, Ashish D. Diwan, Zhaomin Zheng   +13 more
wiley   +1 more source

Microscopic images of the MCF-7 and MCF-7-derived sphere cells and quantitative RT-PCR analysis of candidates.

, 2016
A. Parental MCF-7 cells. B. MCF-7-derived sphere cells. C. Quantitative RT-PCR results of six candidates (IL12RB2, CXCL1, CXCR4, ACADM, BCKDHB and HMGCS1). M indicates parental MCF-7 cells, and S indicates MCF-7-derived sphere cells.
Sang Jun Yoon (1805686), Sang Cheol Kim (137613), Jung-Ho Yoon (1805689), You-Sun Kim (236014), Johan Lim (517839), Jeong Hill Park (517837), Sung Won Kwon (498034), Won Jun Lee (517835)   +7 more
core   +1 more source

Molecular and phenotypic characteristics of seven novel mutations causing branched-chain organic acidurias

, 2016
Specific mitochondrial enzymatic deficiencies in the catabolism of branched-chain amino acids cause methylmalonic aciduria (MMA), propionic acidemia (PA) and maple syrup urine disease (MSUD).
Sarajlija, A., Desviat, L. R., Rodriguez-Pombo, P., Karan-Đurašević, Teodora, Perez, B., Stojiljković, Maja, Kostić, Jelena, Pavlović, Sonja, Kecman, B., Đorđević, M., Grković, S., Brasil, S.   +11 more
core   +1 more source