Results 131 to 140 of about 232,551 (308)

Effect of transport stress on apoptosis and autophagy in goat lung cells

Frontiers in Veterinary Science
IntroductionRoad transportation exposes goats to thermal, mechanical, and microbial stressors that can compromise their welfare by triggering pulmonary apoptosis and autophagy processes associated with tissue damage and immunosuppression.MethodsTo ...
Yu Zhuo, Yunhai Hu, Yangshan Jin, Tian Ye, Yanzhen Yang, Ben Liu, Ben Liu, Ben Liu, Wenya Zheng, Wenya Zheng, Songlin Ding, Xue Yang, Xue Yang, Lucheng Zheng, Lucheng Zheng, Wei Hu, Wei Hu, Manxin Fang, Manxin Fang, Wanting Yi, Wenjing Xing   +20 more
doaj   +1 more source

Correlation of the expression of inflammatory factors with expression of apoptosis-related genes Bax and Bcl-2, in burned rats

Experimental and Therapeutic Medicine, 2018
Correlation of the expression of inflammatory factors with expression of apoptosis-related genes, B-cell lymphoma 2 (Bcl-2) and Bcl-2 associated X protein (Bax), in burned rats was investigated.
Zhixue Wang, J. Fang, Jizhou Xiao
semanticscholar   +1 more source

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

Advanced Science, EarlyView.
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei, Yihan Wang, Jingxia Chen, Jing Zhou, Yuzhu Han, Xiuyu Liu, Siyu Chen, Sheng Chen, Dixin He, Yunxiao Wu, Huixin Lv, Yanmin Zhou   +11 more
wiley   +1 more source

Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy [PDF]

, 2017
BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anti-cancer targets. Using small cell lung cancer (SCLC) as a model, we demonstrated the presence of differential addiction of cancer cells to anti-apoptotic BCL-2, BCL-
Chen, Hui-Chen, Cheng, Emily H, Dong, Yiyu, Ganesan, Yogesh Tengarai, Han, Song, Hellmann, Matthew D, Hsieh, James J, Inoue-Yamauchi, Akane, Ishizawa, Kota, Jebiwott, Sylvia, Jeng, Paul S, Kim, Kwanghee, Kris, Mark G, Pietanza, Maria C   +13 more
core   +2 more sources

In vivo and in vitro induction of the apoptotic effects of oxysophoridine on colorectal cancer cells via the Bcl-2/Bax/caspase-3 signaling pathway

Oncology Letters, 2017
Oxysophoridine (OSR) is a major active alkaloid extracted from Sophoraalopecuroides L. The aim of the present study was to investigate the induction of the apoptotic effects of OSR on colorectal cancer cells in vivo and in vitro.
Shao-Ju Jin, Yun Yang, Lei Ma, Benigno Ma, Liping Ren, Liucheng Guo, Wen-Bao Wang, Yan-Xin Zhang, Zhi-Jun Zhao, M. Cui   +9 more
semanticscholar   +1 more source

Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery

Advanced Science, EarlyView.
Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai, Shasha Zhang, Mingchen Dai, Pei Jiang, Jingyuan Huang, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Jun He, Qiuyue Mao, Yintao Wang, Zixuan Ye, Tian Wang, Renjie Chai   +14 more
wiley   +1 more source

Regulation of cell death in cancer - possible implications for immunotherapy [PDF]

, 2013
Since most anticancer therapies including immunotherapy trigger programmed cell death in cancer cells, defective cell death programs can lead to treatment resistance and tumor immune escape.
Fulda, Simone
core   +2 more sources

Anticancer Effects of Cyclocarya paliurus Polysaccharide (CPP) on Thyroid Carcinoma In Vitro and In Vivo

International Journal of Polymer Science, 2018
In this study, we explored the role and mechanisms of Cyclocarya paliurus polysaccharide on cell apoptosis in thyroid cancer (TC) cells. The apoptosis of thyroid cancer cells in vitro and tumor tissues in vivo induced by Cyclocarya paliurus ...
Zhiwei He, Fangfang Lv, Yueli Gan, Jing Gu, Ting Que   +4 more
doaj   +1 more source

Bufalin induced apoptosis in SCC-4 human tongue cancer cells by decreasing Bcl-2 and increasing Bax expression via the mitochondria-dependent pathway

Molecular Medicine Reports, 2017
The aim of the present study was to investigate the cytotoxic effects of bufalin on SCC-4 human tongue cancer cells. Cell morphological changes and viability were examined using phase contrast microscopy and flow cytometry, respectively.
Han-Yu Chou, F. Chueh, Yi‐Shih Ma, R. Wu, Ching‐Lung Liao, Y. Chu, M. Fan, Wen-Wen Huang, Jing-Gung Chung   +8 more
semanticscholar   +1 more source

Mesoporous Gold Nanospheres Confined Platinum Nanoclusters as Robust ROS and Oxygen Nanogenerators for NIR‐II Hyperthermia Cancer Therapy

Advanced Science, EarlyView.
Mesoporous gold nanospheres confined platinum nanoclusters (MGNSs@Pt) is developed as robust hydroxyl radical and oxygen nanogenerators for multimodal therapies. Their NIR‐II LSPR property also allowed MGSNs to be ideal phototheranostic agents. The chemodynamic and photothermal therapy efficiently induced the tumor cell apoptosis, enabling the MGNSs@Pt
Fei Cun, Jie Chen, Hanxue Li, Yufang Kou, Meiyan Wang, Xiaomin Li, Hui Chen, Jilie Kong   +7 more
wiley   +1 more source