Results 121 to 130 of about 213,161 (287)

Esophageal squamous cell carcinomas and expression of p53, Bcl-2, and Bcl-X(L) [PDF]

, 2008
p53 protein promotes apoptosis, whereas Bcl-2 family proteins have an antiapoptotic function. This study determines the predictive value of selected clinical and histopathological factors in correlation with the expression of p53, Bcl-2, and Bcl-X(L ...
Papadopoulos, J., Siafakas, N., Karameris, A., Vlachos, K., Hakim, N., Theodoropoulos, G., Parassi, E., Peros, G.   +7 more
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Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1 [PDF]

, 2012
Background Bcl-2 is believed to contribute to melanoma chemoresistance. However, expression of Bcl-2 proteins may be different among melanomas. Thus correlations among expression of Bcl-2-related proteins and in vivo melanoma progression, and resistance ...
Priego, Sonia, Mena Salvador, Bob D. Brown, Salvador Mena, Estrela, Jose M., Rodriguez María L, Sonia Priego, Brown Bob D, Miguel Asensi, Cerdá Miguel, Maria L. Rodriguez, Angel Ortega, Obrador, Elena, Priego Sonia, Asensi Miguel, Cerda, Miguel, Miguel Cerda, Ortega, Ángel, Brown, Bob D., Ortega Angel, Ignacio Petschen, Obrador Elena, Elena Obrador, Rodríguez, Maria L., Petschen Ignacio, Jose M. Estrela, Mena-Mollá, Salvador, Asensi, Miguel, Estrela José M, Petschen, Ignacio   +29 more
core   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Effects of Bcl-2 and Bcl-X(L) protein levels on chemoresistance of hepatoblastoma HepG2 cell line [PDF]

, 2000
The ratio between apoptotic promoters and repressors in the Bcl-2 family determines the chemosensitivity of cells to apoptotic stimuli. This study examines the chemoresistance of a transfected human hepatoblastoma HepG2 cell-line during Taxol and ...
Luo, Dan, Chak-Sum Cheng, Samuel, Xie, Hong, Xie, Yong   +3 more
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Survivin, bcl-2, bax, and bcl-X gene expression in sentinel lymph nodes from melanoma patients [PDF]

, 2003
PURPOSE: The expression of apoptosis-related genes, such as survivin, bcl-2, bcl-X, and bax, has been evaluated by reverse transcriptase polymerase chain reaction (RT-PCR) and by immunohistochemistry in sentinel lymph nodes (SLNs) from melanoma patients ...
GRADILONE, Angela, INNOCENZI, Daniele, AGLIANO', Anna Maria, BOTTONI, Ugo, CALVIERI, Stefano, FRATI, Luigi, SCARPA, Susanna, RIBUFFO, Diego, CIGNA, EMANUELE, Fortunata Vasaturo, GAZZANIGA, PAOLA, SCUDERI, Nicolo'   +11 more
core   +1 more source

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

Efeito do óxido nítrico nos mecanismos envolvidos na resistência a daunorrubicina em células de linhagem de leucemia mielóide aguda humana [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2010A Daunorrubicina (DNR) é amplamente utilizada na fase de indução do tratamento da Leucemia Mielóide ...
Curta, Juliana Costa
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Differential regulation of Bax, Bcl-2, and Bcl-X proteins in focal cortical ischemia in the rat [PDF]

, 1998
Focal ischemia in the parietal cortex of the rat results in massive neuronal death in the infarct zone and penumbra between 12 hours and 6 days after photothrombosis.
Krajewski, Stanislaw, Schroeter, Michael, Isenmann, Stefan, Bähr, Mathias, Reed, John C., Stoll, Guido   +5 more
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Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

Detecção imunoistoquímica de fatores relacionados à proliferação celular e ao mecanismo da apoptose em cistos radiculares e dentígeros [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Odontologia, Florianópolis, 2009.Esse estudo propôs investigar os aspectos relacionados à proliferação celular e ao mecanismo da ...
Martins, Caroline Alberici
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