Results 271 to 280 of about 232,551 (308)

Magnesium-assisted hydrogen improves isoproterenol-induced heart failure. [PDF]

Med Gas Res
Chen F, Chen R, Yang L, Shen B, Wang Y, Gao Y, Tan R, Zhao X.   +7 more
europepmc   +1 more source

Targeting SHP‐1‐Mediated Inhibition of STAT3 and ERK Signalling Pathways Rescues the Hyporesponsiveness of MHC‐I‐Deficient NK‐92MI

Cell Proliferation, EarlyView.
B2M knockout (KO) represents a crucial strategy for generating universal NK‐92MI cell products. This approach results in increased phosphorylation of SHP‐1 and inhibited phosphorylation of STAT3 and ERK, which ultimately affect their cytotoxic capabilities. SHP‐1 KO facilitates the restoration of cytotoxic function in B2M KO NK‐92MI cells.
Kuo Yu, Xiaolong Liu, Guangyuan Wu, Zhongyao An, Xin Wang, Yang Liu, Hailong Wang, Mingli Huang, Linlin Zhao, Ce Shi, Xin Sun, Lu Xu, Sen Qi, Xin Zhang, Yueqiu Teng, Song Guo Zheng, Zhiren Zhang, Zhenkun Wang   +17 more
wiley   +1 more source

Alternative Splicing in Tumorigenesis and Cancer Therapy. [PDF]

Biomolecules
Chen H, Tang J, Xiang J.
europepmc   +1 more source

Synergistical Induction of Apoptosis via Cold Atmospheric Plasma and Nanohydroxyapatite for Selective Inhibition of Oral Squamous Cell Carcinoma in Tumour Microenvironment

Cell Proliferation, EarlyView.
The synergistic effects of microwave‐induced CAP and pH‐responsive NH2‐nHA on OSCC cells were investigated, unveiling novel molecular mechanisms. The study highlights CAP+NH2‐nHA's dual action, inducing diverse apoptotic pathways and establishing a ROS‐Ca2+ amplifying loop, promising in cancer therapy.
Wenting Qi, Hanghang Liu, Huaze Liu, Yuxuan Guo, Li Wu, Chongyun Bao, Xian Liu   +6 more
wiley   +1 more source

Niclosamide Treatment Suppressed Metastatic, Apoptotic, and Proliferative Characteristics of MDA-MB-231 Cancer Stem Cells. [PDF]

ACS Omega
Altundag-Erdogan Ö, Çelebi-Saltik B.
europepmc   +1 more source

Research Advances of the Autophagy‐Regulated Radiosensitivity

Cell Proliferation, EarlyView.
Autophagy plays a dual role in regulating cellular radiosensitivity in radiotherapy (RT). We discuss the mechanisms by which autophagy promotes survival and growthsuppression by modulating radiosensitivity. It also outlines some frontier autophagy‐targeted radiotherapies. ABSTRACT Autophagy is an evolutionarily conserved process of cell self‐catabolism
Hanyue Liu, Yanlan Xiao, Chuhao Dai, Keyu Chen, Xinyi Xu, Jianming Cai, Xuguang Hu, Jiaming Guo   +7 more
wiley   +1 more source

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, EarlyView.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

Development of a Novel Biomarker Platform for Profiling Key Protein-Protein Interactions to Predict the Efficacy of BH3-Mimetic Drugs. [PDF]

Cancers (Basel)
Kinloch AJ, Rahman F, Karakas B, Shahid M, Lim B, Bouley SJ, Walker JA, Lee EF, Fairlie WD, Kelly KR, Cardone MH.   +10 more
europepmc   +1 more source

Anticancer Potential of Myricetin against Huh7- and Hep3B-Derived Liver Cancer Stem Cells through the Regulation of Apoptosis, Autophagy, and Stemness. [PDF]

Biomol Ther (Seoul)
Kwon M, Jung HJ.
europepmc   +1 more source

Rhein-induced apoptosis in colorectal cancer cell lines: A mechanistic study of the myeloid differentiation primary response gene 88/toll-like receptor 4/nuclear factor kappa-B signaling pathway.

Cytojournal
Zheng X, Zhang X, Hu L, Chen X, Zhao Z, Mao L.   +5 more
europepmc   +1 more source