Results 261 to 270 of about 213,161 (287)

Long noncoding RNA DINO (damage induced noncoding) represses the development of gastric cancer by modulating p21 and Bcl‐2 Associated X Protein (Bax) expression

Journal of Cellular Biochemistry, 2019
AbstractlncRNAs are responsible for a variety of diseases, including gastric cancer (GC). Many recent studies have reported that lncRNAs can serve as crucial regulators of various genes. Nevertheless, the biological function of lncRNA damage induced noncoding (DINO) remained poorly investigated in GC.
Qinqiang Liu, Yan Xiao, Peng Cai, Jun Li, Dawei Li   +4 more
openaire   +2 more sources

BIM (BCL-2 interacting mediator of cell death) SAHB (stabilized α helix of BCL2) not always convinces BAX (BCL-2-associated X protein) for apoptosis

Journal of Molecular Graphics and Modelling, 2016
The interaction of BAX (BCL-2-associated X protein) with BIM (BCL-2 interacting mediator of cell death) SAHB (stabilized α helix of BCL2) directly initiates BAX-mediated mitochondrial apoptosis. This molecular dynamics study reveals that BIM SAHB forms a stable complex with BAX but it remains in a non-functional conformation.
Sharad, Verma, Sukriti, Goyal, Chetna, Tyagi, Salma, Jamal, Aditi, Singh, Abhinav, Grover   +5 more
openaire   +2 more sources

Establishment of a specific cell death induction system in Bombyx mori by a transgene with the conserved apoptotic regulator, mouse Bcl‐2‐associated X protein (mouse Bax)

Insect Molecular Biology, 2015
Abstract The induction of apoptosis in vivo is a useful tool for investigating the functions and importance of particular tissues. B‐cell leukaemia/lymphoma 2‐associated X protein (Bax) functions as a pro‐apoptotic factor and induces apoptosis in several organisms.
M, Sumitani, T, Sakurai, K, Kasashima, S, Kobayashi, K, Uchino, R, Kanzaki, T, Tamura, H, Sezutsu   +7 more
openaire   +2 more sources

Protective mechanism of gallic acid and its novel derivative against ethanol-induced gastric ulcerogenesis: Involvement of immunomodulation markers, Hsp70 and Bcl-2-associated X protein

International Immunopharmacology, 2013
Some phytochemicals demonstrate gastroprotective effects by inhibiting gastric acid secretion or through antioxidant action. One of these antioxidant phytochemicals which have been studied is gallic acid. However, its mechanism in the treatment and prevention of gastric ulcer remains unclear.
openaire   +2 more sources

Near-infrared-inducible Bcl-2-associated X protein system for apoptosis regulation in vivo

Chemical Engineering Journal, 2023
Shiqi Lin, Jinbin Pan, Xingtai Huang, Zihan Wang, Xiujuan Zhao, Shao-Kai Sun   +5 more
openaire   +1 more source

[The relationship between frameshift mutations of transforming growth factor-beta type II receptor, insulin growth factor II receptor, bcl-2 associated X protein, E2F4 and microsatellite instability in gastric carcinoma].

Zhonghua wai ke za zhi [Chinese journal of surgery], 2007
To determine the microsatellite instability in gastric carcinomas, examine the frameshift mutations of transforming growth factor-beta type II receptor (TGFbetaRII), insulin growth factor II receptor (IGFIIR), bcl-2 associated X protein (BAX) and E2F4, and investigate whether or how alterations of the TGFbetaRII, IGFIIR, BAX and E2F4 gene are ...
Guo-ting, Chen, Zheng-gang, Zhu, Hao-ran, Yin, Bing-ya, Liu, Jun, Ji, Jun, Zhang, Yan-zhen, Lin   +6 more
openaire   +1 more source

BCL-2 protein family: attractive targets for cancer therapy

Apoptosis: an International Journal on Programmed Cell Death, 2022
Sarah T Diepstraten, Andreas Straßer, Gemma L Kelly   +2 more
exaly  

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Nature Reviews Molecular Cell Biology, 2013
Peter E Czabotar, Guillaume Lessene, Andreas Straßer   +2 more
exaly  

Bcl-2-Associated X Protein

2018
openaire   +1 more source

The role of the Bcl-2 protein family in cancer

Seminars in Cancer Biology, 2003
Leigh Coultas, Andreas Straßer
exaly