Results 131 to 140 of about 369,993 (297)
Advanced Science, EarlyView.Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai +14 more
wiley +1 more source
Synergistic Bcl-2 inhibition by ABT-737 and cyclosporine A [PDF]
, 2018 Survival of lymphocytes and melanocyte stem cells critically depends on B cell lymphoma 2 (Bcl-2). In T lymphocytes, a basal calcineurin activity maintains Bcl-2 expression in naïve cells, and the activation of the calcineurin pathway orchestrates the ...
Chen, Jin +6 more
core
Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes. [PDF]
, 1994 Mildred Lam +5 more
openalex +1 more source
Advanced Science, EarlyView.Mesoporous gold nanospheres confined platinum nanoclusters (MGNSs@Pt) is developed as robust hydroxyl radical and oxygen nanogenerators for multimodal therapies. Their NIR‐II LSPR property also allowed MGSNs to be ideal phototheranostic agents. The chemodynamic and photothermal therapy efficiently induced the tumor cell apoptosis, enabling the MGNSs@Pt
Fei Cun +7 more
wiley +1 more source
bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells [PDF]
, 1992 D Delia +7 more
openalex +1 more source
Advanced Science, EarlyView.A novel Janus Ag/Ag2S nanostructure grafted with dimer PD‐L1 affibody (AMZ) is successfully developed. AMZ can be used as ROS nanocatalyst to achieve tumor radiosensitization, and it can also act as an ROS eliminator to alleviate radiation enteritis, achieving a radiotherapy strategy characterized by “toxicity reduction and efficacy enhancement ...
Mengmeng Zhang +12 more
wiley +1 more source
Detection by polymerase chain reaction of residual cells with the bcl-2 translocation is associated with increased risk of relapse after autologous bone marrow transplantation for B-cell lymphoma [PDF]
, 1993 JG Gribben +9 more
openalex +1 more source
Advanced Science, EarlyView.A structure‐guided peptide derived from a non‐canonical amino acid library simultaneously targets MCL‐1 and BCL‐xL to overcome apoptotic resistance in acute myeloid leukemia. Fused with a CXCR4‐binding motif, the engineered peptide exhibits selective intracellular delivery and potent in vivo efficacy, offering a promising therapeutic strategy against ...
Zhe Wang +11 more
wiley +1 more source
In vitro evaluation of In-111-DOTA-anti-bcl-2-PNA-Tyr-3-octreotate in Chronic Lymphocytic Leukemia cells [PDF]
, 2005 only availableThe B-cell lymphoma/leukemia-2 (bcl-2) gene is overexpressed in many cancers. This gene increases cell survival by blocking apoptosis, or programmed cell death.
Hunter, Charles +2 more
core
Advanced Science, EarlyView.The bacterial Type VI secretion system (T6SS) emerges as a sophisticated virulence mechanism, leveraging the dual‐function effector TkeA from Yersinia pseudotuberculosis. TkeA concurrently damages rival bacteria and host cell DNA, triggering the host's cGAS‐STING‐TNF pathway and inducing apoptosis.
Li Song +13 more
wiley +1 more source