Results 131 to 140 of about 408,548 (333)

His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models

Advanced Science, EarlyView.
His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li, Tianqi Su, Bin Zhang, Wenkai Han, Sibin Zhang, Guiyin Sun, Yuwei Cong, Xin Chen, Jiping Qi, Yujie Wang, Shiguang Zhao, Hongxue Meng, Peng Liang, Xin Gao   +13 more
wiley   +1 more source

Морфометричні зміни Bcl-2+-клітин кори тім’яної частки, індуковані неповною глобальною ішемією-реперфузією головного мозку в самців-щурів зі стрептозотоциновим цукровим діабетом [PDF]

, 2016
Досліджено динаміку реакції морфометричних параметрів Bcl-2+-нейронів та гліальних клітин кори тім’яної частки на неповну глобальну ішемію-реперфузію в щурів без цукрового діабету та з наявністю останнього.
Бойчук, Тарас Миколайович, Кметь, Ольга Гнатівна, Кметь, Тарас Ігорович   +2 more
core  

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, EarlyView.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source

Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context

Egyptian Journal of Medical Human Genetics
Apoptosis, also known as the programmed death of cells, is responsible for maintaining the homeostasis of tissues, and this function is carried out by caspases.
Md. Saddam, Shamrat Kumar Paul, Mohammad Ahsan Habib, Md. Abrar Fahim, Afsana Mimi, Saiful Islam, Bristi Paul, Md Mostofa Uddin Helal   +7 more
doaj   +1 more source

Single‐Cell Transcriptomic Atlases of Camels and Cattle Unravel Molecular Evolution of Digestive and Metabolic Systems

Advanced Science, EarlyView.
We generated multi‐tissue single‐cell transcriptomic atlases of camels and cattle, uncovering conserved and lineage‐specific cellular features across digestive and metabolic systems. Cross‐species comparisons revealed the evolutionary origin of the camel glandular sac and identified novel cell populations linked to physiological specialization ...
Tao Shi, Huiquan Shan, Haoping Wang, Xi Guo, Houcheng Li, Bo Han, Senlin Zhu, Fei Wang, Guanghui Tan, Zhannur Niyazbekova, Jilong Ren, Yaqi Zhou, Qi Zhang, Weijie Zheng, Minghui Jia, Ao Zhang, Xuesha Cao, Huizeng Sun, Dongxiao Sun, Lingzhao Fang, Yi Zheng, Xihong Wang, Yu Jiang   +22 more
wiley   +1 more source

CRISPR‐Cas9‐Loaded Theranostic Liposomes for Enhancing Radiosensitization of Prostate Cancer through POLD4 Gene Editing under Real‐Time MRI Monitoring

Advanced Science, EarlyView.
This study identifies POLD4 as a potential prostate cancer radiosensitization target through transcriptome sequencing. By encapsulating POLD4‐targeted CRISPR/Cas9 plasmids and USPIONs in cationic liposomes, an MRI‐monitored gene‐editing platform is established.
Xuhui Fan, Ruru Zhang, Linjun Yang, Shixiong Chen, Meijuan He, Yongqiang Wang, Linjie Huang, Jianfeng Zeng, Shuwang Wu, Mingyuan Gao, Han Wang   +10 more
wiley   +1 more source

Computational Exploration of Betulinic Acid Hybrids as Dual BCL-2/BCL-XL Inhibitors

Proceedings
Betulinic acid (BA), a lupane-type triterpene widely studied for its selective cytotoxicity against malignancies [...]
Elisabeta P. Atyim, Marius Mioc, Codruța Șoica   +2 more
doaj   +1 more source

Effects of the Esterified Quercetin with omega3 and omega6 fatty acids on cell viability and BAX and BCL-2 gene expression in MCF-7 Human Breast Cancer Cell Line. [PDF]

, 2021
leila soufi, Nematollah Gheibi, Alireza Farasat, Hossein Ahmadpour Yazdi   +3 more
openalex  

Рання та відстрочена реакція білка bcl-2 в нервових і гліальних клітинах кори лобової частки півкуль головного мозку щурів з експериментальним цукровим діабетом на гостре порушення кровообігу в басейні сонних артерій [PDF]

, 2016
Досліджено активність антиапоптичних процесів у нейронах та гліальних клітинах кори лобової частки за змінами вмісту білка Bcl-2 в щурів зі стрептозотоцин-індукованим цукровим діабетом у динаміці ішемічно-реперфузійного пошкодження головного мозку ...
Кметь, Тарас Ігорович
core  

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source