Results 131 to 140 of about 17,898,482 (301)

Induction of apoptosis and enhancement of chemosensitivity in human prostate cancer LNCaP cells using bispecific antisense oligonucleotide targeting Bcl-2 and Bcl-xL genes

, 2006
OBJECTIVE: To determine whether a specifically designed bispecific (Bcl-2/Bcl-xL) antisense oligonucleotide (ASO) induces apoptosis and enhances chemosensitivity in human prostate cancer LNCaP cells, as Bcl-2 and Bcl-xL are both anti-apoptotic genes ...
Miyake, Hideaki, Zangemeister-Wittke, Uwe, Fazli, Ladan, So, Alan, Yamanaka, Kazuki, Rocchi, Palma, Gleave, Martin E   +6 more
core   +1 more source

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

Bcl-rambo induced apoptosis in Drosophila S2 cells.

, 2016
(A) S2 cells were transfected with pAct5C-GAL4 together with pUAST, pUAST-Bcl-rambo, pUAST-Bcl-rambo (ΔTM), pUAST-Bcl-rambo (TM), or pUAST-DsRed-monomer for 24 h. Cells were stained with Hoechst 33342.
Masamitsu Yamaguchi (33991), Nicole Vo (119001), Takao Kataoka (2144404), Megumi Watanabe (223693), Hideki Yoshida (545135), Mako Nakazawa (3163593), Yuka Matsushita (3163599), Hisanori Matsubara (3163596)   +7 more
core   +1 more source

Chrysin alleviates pressure overload–induced myocardial remodeling through regulating the PI3K/AKT/NRF2 pathway–mediated oxidative stress response

Animal Models and Experimental Medicine, EarlyView.
In this study, we primarily simulated pathological myocardial remodeling induced by transverse aortic constriction surgery and found significant cardiac hypertrophy and fibrosis, characterized by deteriorated cardiac function. Oxidative stress response is considered as a pivotal pathological process, which contributes to inflammation and apoptosis of ...
Yijia Wang, Xing Feng, Shuhui Zhao, Yuchong Fu, Ao Zhang, Xiaofeng Shen, Bowen Yu, Yihao Wang, Jiahui Lin, Bing Zhang, Weiping Ji, Lianpin Wu, Xiaoling Guo   +12 more
wiley   +1 more source

RELATIONSHIP BETWEEN APOPTOSIS MARKERS(P53, BCL-2, BAX) AND CLINICAL-MORPHOLOGICAL PARAMETERS AND SURVIVAL IN NON-SMALL CELL LUNG CANCER

Сибирский онкологический журнал, 2016
The purpose of the study was to analyze the relationship between expression of the р53, bcl-2 and bax genes and clinical-morphological parameters and survival in patients with non-small cell lung cancer (NSCLC).
D. S. Kobyakov, А. F. Lazarev, Е. L. Lushnikova, L. M. Nepomnyashchikh   +3 more
doaj  

Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context

Egyptian Journal of Medical Human Genetics
Apoptosis, also known as the programmed death of cells, is responsible for maintaining the homeostasis of tissues, and this function is carried out by caspases.
Md. Saddam, Shamrat Kumar Paul, Mohammad Ahsan Habib, Md. Abrar Fahim, Afsana Mimi, Saiful Islam, Bristi Paul, Md Mostofa Uddin Helal   +7 more
doaj   +1 more source

Inhibition of Antiapoptotic BCL-XL, BCL-2, and MCL-1 Proteins by Small Molecule Mimetics

, 2010
Informatics and computational design methods were used to create new molecules that could potentially bind antiapoptotic proteins, thus promoting death of cancer cells. Apoptosis is a cellular process that leads to the death of damaged cells.
G. Prisco, D.S. Dalafave
core  

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

BCL-2 family isoforms in apoptosis and cancer

The BCl-2 family has long been identified for its role in apoptosis. Following the initial discovery of BCL-2 in the contextof B-cell lymphoma in the 1980s, a number of homologous proteins have since been identified.
Michelle W. Wong-Brown (10660741), Nikola Bowden (21136433), Chloe F. A. Warren (21314846)   +2 more
core  

Bcl-rambo did not interact genetically with Drob-1 or Buffy.

, 2016
(A and B) Bcl-rambo and Bcl-rambo (ΔTM) were expressed using GMR-GAL4 driver fly lines. (A) (a, f, k) GMR-GAL4/w; UAS-Bcl-rambo/+; +, (b, g, l) GMR-GAL4/w; UAS-Bcl-rambo/Drob-1E26; +, (c, h, m) GMR-GAL4/w; UAS-Bcl-rambo/Drob-1W105; +, (d, i, n) GMR-GAL4 ...
Masamitsu Yamaguchi (33991), Nicole Vo (119001), Takao Kataoka (2144404), Megumi Watanabe (223693), Hideki Yoshida (545135), Mako Nakazawa (3163593), Yuka Matsushita (3163599), Hisanori Matsubara (3163596)   +7 more
core   +1 more source