Results 171 to 180 of about 377,868 (302)

Avoiding Mitochondrial Apoptosis by the Bcl-2-Driven Bax Oligomerization on Membrane Surfaces. [PDF]

ACS Chem Biol
Ayscough SE, Clifton LA, Ådén J, Köhler S, Paracini N, Doutch J, Bragginton ÉC, Leung AE, Bogojevic O, Poon JF, Nagy TM, Wacklin-Knecht HP, Gröbner G.   +12 more
europepmc   +1 more source

ChatGPT, Claude Sonnet, and Grok Display Similarly Low Rates of Accuracy in Identifying Image‐Based Orthopaedic Sports Pathologies

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To assess the ability of artificial intelligence (AI) to identify common sports‐related pathologies using radiologic imaging and to compare ChatGPT 4.0 with 2 competitors, Grok 2 and Claude 3.5 Sonnet. Methods ChatGPT 4.0, Grok 2, and Claude 3.5 Sonnet were used. Five common orthopaedic sports pathologies were chosen: anterior cruciate ligament
Ahmad R. Alhankawi, Collin L. Braithwaite, Alejandro M. Holle, M. Lane Moore, Saad Tarabichi, Anikar Chhabra   +5 more
wiley   +1 more source

DrugBank mining with machine learning reveals novel candidates for BCL-2 inhibition. [PDF]

Sci Rep
Park J, Cho S, Lee H, Choi YR, Choi DH, Jeong MY, Lim YS, Hwang SB, Choi J.   +8 more
europepmc   +1 more source

Interleukin‐5, Eosinophils, and Interleukin‐5 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Dynamical analysis of a model of BCL-2-dependent cellular decision making. [PDF]

NPJ Syst Biol Appl
Cloete I, Alarcón T.
europepmc   +1 more source

Bacterial Pigments as Potential Antitumor Agents Against Gastrointestinal Cancers: A Comprehensive Systematic Review

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Gastrointestinal cancers (GICs) constitute one of the leading causes of cancer‐related morbidity and mortality worldwide. Despite currently available therapeutic strategies, new approaches and procedures are needed for their prevention and treatment.
Raúl Vergara, Ricardo F. S. Pereira, Carla C. C. R. de Carvalho, Jose Prados, Consolación Melguizo, Raul Ortiz   +5 more
wiley   +1 more source

Green-synthesized Desertifilum silver nanoparticles induce BAX/BCL-2 mediated apoptosis in Ehrlich carcinoma. [PDF]

BMC Biotechnol
Hanna AL, Elgebaly AS, Mohmed MM, Sadik MW, Hamouda HM, Goda HA, Altrawy A.   +6 more
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Crossing ocular barriers with quercetin-SPIONs: modulation of Bax/Bcl-2 balance in normal rat eyes. [PDF]

BMC Pharmacol Toxicol
Hajiaghajanian M, Movahedi N, Pouriaii D, Souri Z, Rezayat A, Esmaeili A.   +5 more
europepmc   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source