Results 291 to 300 of about 21,951,536 (341)
Production and characterization of a promising microbial-derived lipase enzyme targeting BCL-2 gene expression in hepatocellular carcinoma. [PDF]
Microb Cell FactAbo-Kamer AM +3 more
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RETRACTION: LncRNA TUG1 Relieves Renal Mesangial Cell Injury by Modulating the miR-153-3p/Bcl-2 Axis in Lupus Nephritis. [PDF]
Immun Inflamm Diseuropepmc +1 more source
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Current Opinion in Oncology, 2009
Members of the Bcl-2 family of proteins are critical components in regulating the intrinsic apoptotic pathway. Bcl-2 protein overexpression is associated with drug resistance and poor clinical outcome in cancer patients. Preclinical and clinical evaluations demonstrate that downregulation of Bcl-2 restores the intrinsic apoptotic pathways with ...
Aisha Masood +3 more
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Members of the Bcl-2 family of proteins are critical components in regulating the intrinsic apoptotic pathway. Bcl-2 protein overexpression is associated with drug resistance and poor clinical outcome in cancer patients. Preclinical and clinical evaluations demonstrate that downregulation of Bcl-2 restores the intrinsic apoptotic pathways with ...
Aisha Masood +3 more
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The Bcl-2 protein family: arbiters of cell survival.
Science, 1998Bcl-2 and related cytoplasmic proteins are key regulators of apoptosis, the cell suicide program critical for development, tissue homeostasis, and protection against pathogens.
Jerry M. Adams, S. Cory
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New insights in the role of Bcl-2 Bcl-2 and the endoplasmic reticulum
Apoptosis, 2002The oncogenic protein Bcl-2 which is expressed in membranes of different subcellular organelles protects cells from apoptosis induced by endogenic stimuli. Most of the results published so far emphasise the importance of Bcl-2 at the mitochondria. Several recent observations suggest a role of Bcl-2 at the endoplasmic reticulum (ER).
Justine Rudner +2 more
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Current Medicinal Chemistry, 2012
Chronic lymphocytic leukemia (CLL) is a common adult leukemia in the Western world with an incidence of 4.2/100,000/year. The clinical course of disease is highly heterogenous; it affects people over 65-70 years of age. This hematologic cancer is characterized by the resistance to apoptosis stimuli predominantly associated with overexpression of ...
Kilianska Zm, Rogalinska M
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Chronic lymphocytic leukemia (CLL) is a common adult leukemia in the Western world with an incidence of 4.2/100,000/year. The clinical course of disease is highly heterogenous; it affects people over 65-70 years of age. This hematologic cancer is characterized by the resistance to apoptosis stimuli predominantly associated with overexpression of ...
Kilianska Zm, Rogalinska M
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Bcl-2 Family Immunohistochemistry [PDF]
, 2003 In recent years, immunohistochemistry as applied to the Bcl-2 family of proteins has represented a burgeoning area of interest to cancer researchers. The majority of studies have focused on the original member Bcl-2, first identified via its involvement in the common t(14;18) chromosomal translocation in B-cell lymphomas (1).
Lloyd R. Kelland, Philip Beale
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