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Bcl-2 and Bcl-2-Related Proteins in Apoptosis Regulation
1995In this review we have discussed the importance of Bcl-2 and related proteins in the regulation of apoptotic cell death in mammalian systems. It is clear that Bcl-2 plays a critical role in controlling many forms of PCD. Bcl-2 seems to have particular significance in lymphocyte development and the function of the immune system.
Lawrence H. Boise +3 more
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bcl-2 Expression in Pilomatricoma
The American Journal of Dermatopathology, 1997Pilomatricoma is a distinctive tumor characterized by a dual population of proliferating basophilic cells and diagnostic shadow cells, believed to arise from the hair matrix. The normal hair matrix undergoes defined cycles of growth (anagen), regression (catagen), and resting (telogen) that are regulated by programmed cell death (apoptosis). bcl-2 is a
Sean E. Farrier, Michael B. Morgan
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1999
Apoptosis is an increasingly well described, but still poorly understood, mechanism for killing metazoan cells (Kerr et al. 1972; Wyllie et al. 1980). It is fundamental to processes as diverse as tissue remodelling during embryogenesis, maintenance of tissue homeostasis in the adult and to both innate and cognate immunity (Ellis et al.
Liam O'Connor, Andreas Strasser
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Apoptosis is an increasingly well described, but still poorly understood, mechanism for killing metazoan cells (Kerr et al. 1972; Wyllie et al. 1980). It is fundamental to processes as diverse as tissue remodelling during embryogenesis, maintenance of tissue homeostasis in the adult and to both innate and cognate immunity (Ellis et al.
Liam O'Connor, Andreas Strasser
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2004
A highly regulated network of protein-protein interactions is now known to be the central underlying theme in controlling apoptosis. Understanding the chemical basis of these interactions is a major key to understanding the mechanisms of this diverse pathway, while controlling the outcome of these interactions offers remarkable benefits to the ...
Amelia Petch, Mohamed Al-Rubeai
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A highly regulated network of protein-protein interactions is now known to be the central underlying theme in controlling apoptosis. Understanding the chemical basis of these interactions is a major key to understanding the mechanisms of this diverse pathway, while controlling the outcome of these interactions offers remarkable benefits to the ...
Amelia Petch, Mohamed Al-Rubeai
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Bcl-2 family on guard at the ER
American Journal of Physiology-Cell Physiology, 2009The endoplasmic reticulum (ER) is the main site for protein folding, lipid biosynthesis, and calcium storage in the cell. Disturbances of these critical cellular functions lead to ER stress. The ER responds to disturbances in its homeostasis by launching an adaptive signal transduction pathway, known as the unfolded protein response (UPR).
Samali, Afshin +4 more
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A role for calcium in Bcl-2 action?
Biochimie, 2002Changes in the cytosolic Ca(2+) concentration ([Ca(2+)](c)) translate a variety of extracellular signals into widely diverse intracellular effects, ranging from secretion to movement, proliferation and also cell death. As regards the last one, it has long been known that large [Ca(2+)](c) increases lead cells to death.
PINTON, Paolo +5 more
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Mechanisms of BCL-2 family proteins in mitochondrial apoptosis
Nature reviews. Molecular cell biology, 2023P. Czabotar, A. García-Sáez
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Role of Caspase 3-Dependent Bcl-2 Cleavage in Potentiation of Apoptosis by Bcl-2
Molecular Pharmacology, 2002Previous studies from our laboratory have demonstrated that Bcl-2 has a proapoptotic effect on neocarzinostatin (NCS)-treated PC12 pheochromocytoma cells. In the present study, we examine the mechanisms of this effect and demonstrate its relevance for the in vivo situation. Four hours after NCS treatment, a 23-kDa cleavage product of Bcl-2 was detected
Nina F. Schor +3 more
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Bcl-2 and Bax in congenital naevi
British Journal of Dermatology, 2006Melanocytes represent a static component of the epidermis, and the role of apoptosis in basal melanocyte function and melanocytic tumour formation has not been fully elucidated.The aim of this study was to investigate the expression of Bcl-2 anti-apoptotic and Bax apoptotic proteins in congenital naevi in correlation with p-27 protein and Ki-67 ...
A Katsambas +8 more
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Expression of Bcl-2 Protein and Bcl-2 mRNA in Normal and Neoplastic Lymphoid Tissues
Leukemia & Lymphoma, 1994The bcl-2 gene is a unique proto-oncogene that blocks apoptosis; its product is localized on the inner mitochondrial membrane. In non neoplastic human lymphoid tissues, bcl-2 protein is strongly expressed in the small recirculating lymphocytes of the follicular mantle zone; it is expressed less intensely in T-cell areas, and is almost absent from ...
Eisaku Kondo +2 more
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