Results 311 to 320 of about 21,951,536 (341)

BCL-2 in prostate cancer: A minireview

Apoptosis, 2003
Prostate cancer progression and the development of androgen-independent prostate cancer have been largely related to a number of genetic abnormality that affect not only the androgen receptor but also crucial molecules involved in the regulation of survival or apoptotic pathways.
Sergio D. Catz, Jennifer L. Johnson
openaire   +2 more sources

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.

Science, 2000
A critical function of tumor suppressor p53 is the induction of apoptosis in cells exposed to noxious stresses. We report a previously unidentified pro-apoptotic gene, Noxa. Expression of Noxa induction in primary mouse cells exposed to x-ray irradiation
Eri Oda, Rieko Ohki, H. Murasawa, J. Nemoto, T. Shibue, T. Yamashita, T. Tokino, T. Taniguchi, N. Tanaka   +8 more
semanticscholar   +1 more source

Bcl-2–related antisense therapy

Seminars in Oncology, 2002
High expression of the bcl-2 proto-oncogene is found in various human hematologic malignancies and solid tumors. Bcl-2 protein exerts its oncogenic role by preventing tumor cells from undergoing apoptosis induced by radiation, chemotherapy, and hormonal therapy.
Pablo Zapata-Benavides, Gabriel Lopez-Berestein, Yolanda Gutierrez-Puente, Ana M. Tari   +3 more
openaire   +3 more sources

Bcl-2 Expression in the Thymus and Periphery

Cellular Immunology, 1994
Bcl-2 proto-oncogene is expressed in normal lymphoid tissues and its role has been suggested to involve the selection of B and T cells. Here we report three-color flow cytometric studies on the expression of bcl-2 protein in the thymus and periphery. Bcl-2 was expressed in the majority of T and B cells and down-regulated only in the CD1+, CD3- to low ...
Meinoshin Okumura, Kazuya Nakahara, Keiji Inada, Yukiyasu Takeuchi, Yoshitaka Fujii, Yoshihide Tsujimoto, Hikaru Matsuda   +6 more
openaire   +3 more sources

BCL-2, a novel regulator of apoptosis

Journal of Cellular Biochemistry, 1996
The bcl-2 gene has a unique function among mammalian oncogenes as a negative regulator of apoptosis. Its expression pattern in embryonic and adult tissues is consistent with a role in maintaining in vivo survival of specific cell types. The biochemical function of bcl-2 is unknown, but its localization to mitochondrial and microsomal membranes suggests
Julie R. Park, David M. Hockenbery
openaire   +3 more sources

The BCL-2 protein family: opposing activities that mediate cell death

Nature reviews. Molecular cell biology, 2008
R. Youle, A. Strasser
semanticscholar   +1 more source

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Nature, 2005
T. Oltersdorf, S. Elmore, A. Shoemaker, R. Armstrong, D. Augeri, B. Belli, M. Bruncko, T. Deckwerth, J. Dinges, P. Hajduk, M. Joseph, S. Kitada, S. Korsmeyer, Aaron R. Kunzer, A. Letai, Chi Li, M. Mitten, D. Nettesheim, S. Ng, Paul M Nimmer, J. O'Connor, Anatol Oleksijew, A. Petros, John Calvin Reed, W. Shen, S. Tahir, C. Thompson, K. Tomaselli, Baole Wang, M. Wendt, Haichao Zhang, S. Fesik, S. Rosenberg   +32 more
semanticscholar   +1 more source

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

Science, 1997
R. Kluck, E. Bossy‐Wetzel, D. Green, D. Newmeyer   +3 more
semanticscholar   +1 more source

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Nature reviews. Molecular cell biology, 2013
P. Czabotar, G. Lessene, A. Strasser, Jerry M. Adams   +3 more
semanticscholar   +1 more source

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Nature Network Boston, 2013
A. Souers, J. Leverson, E. Boghaert, S. Ackler, Nathaniel D. Catron, Jun Chen, B. Dayton, H. Ding, S. Enschede, W. Fairbrother, D. Huang, S. Hymowitz, Sha S. Jin, S. Khaw, P. Kovar, L. Lam, Jackie G. Lee, H. Maecker, K. Marsh, K. Mason, M. Mitten, Paul M Nimmer, Anatol Oleksijew, Chang H. Park, Cheol-min Park, D. Phillips, A. Roberts, D. Sampath, J. Seymour, Morey L. Smith, G. Sullivan, S. Tahir, Chris Tse, M. Wendt, Yu Xiao, John Xue, Haichao Zhang, R. Humerickhouse, S. Rosenberg, S. Elmore   +39 more
semanticscholar   +1 more source