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Adipocyte death promotes hepatic infiltration of S100A8+ macrophages and steatotic liver disease progression in mice. [PDF]
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1995
Abstract Probes for the IgH locus were used to clone t(14; 18) breakpoint DNAs. These DNAs allowed the identification of a transcriptional unit on chromosome 18, which was named bc!2. The bcl2 gene is transcribed by alternative splicing into three mRNAs of different sizes. bcl2 contains two exons and encodes two proteins that only differ
James R Bischoff +1 more
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Abstract Probes for the IgH locus were used to clone t(14; 18) breakpoint DNAs. These DNAs allowed the identification of a transcriptional unit on chromosome 18, which was named bc!2. The bcl2 gene is transcribed by alternative splicing into three mRNAs of different sizes. bcl2 contains two exons and encodes two proteins that only differ
James R Bischoff +1 more
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2008
The Bcl2 family of proteins belong to a peculiar class of proteins regulating apoptosis, cell cycle, differentiation, and autophagy; in oncology, the genes coding for these proteins could not be defined neither as dominant transforming oncogenes (such as myc), nor tumor suppressor genes (such as p53).
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The Bcl2 family of proteins belong to a peculiar class of proteins regulating apoptosis, cell cycle, differentiation, and autophagy; in oncology, the genes coding for these proteins could not be defined neither as dominant transforming oncogenes (such as myc), nor tumor suppressor genes (such as p53).
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Enhancing dendritic cells by inhibiting BCL2
Trends in Cancer, 2023Dendritic cells play an important role in anticancer immunity by exposing T cells to tumor-associated antigens. In a recent study, Zhao et al. show that BCL2 inhibition improves the ability of dendritic cells to present antigen to T cells and activate their antitumor cytotoxicity.
Christopher A G, Booth, Andrew A, Lane
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Novel BCL2 inhibitor, Disarib induces apoptosis by disruption of BCL2-BAK interaction
Biochemical Pharmacology, 2017Apoptosis is a highly regulated pathway of programmed cell death relying on the fine balance between pro and antiapoptotic binding partners. Overexpression of the antiapoptotic protein BCL2 in several cancers makes it an ideal target for chemotherapy, with minimum side effects.
Supriya V, Vartak +11 more
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BCL2: A promising cancer therapeutic target
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2017A remarkable characteristic of majority of cancer cells is that, they fail to undergo apoptosis, which in turn confers them a survival advantage over normal cells. Targeted cancer therapy aims at disrupting the functions of proteins that play an important role during cancer progression.
Radha, Gudapureddy, Raghavan, Sathees C
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Science Signaling, 2008
Bcl2 is an oncogenic protein best known for its role as an inhibitor of apoptosis through its actions at the mitochondria. However, Bcl2 was initially identified as associated with a chromosomal breakpoint, not as a mitochondrial protein, which suggests that it has additional functions beyond those at the mitochondria.
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Bcl2 is an oncogenic protein best known for its role as an inhibitor of apoptosis through its actions at the mitochondria. However, Bcl2 was initially identified as associated with a chromosomal breakpoint, not as a mitochondrial protein, which suggests that it has additional functions beyond those at the mitochondria.
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Venetoclax: Targeting BCL2 in Hematological Cancers
2018Over the last years, targeted anti-cancer therapy with small-molecule inhibitors and antibodies moved to the forefront as a strategy to treat hematological cancers. These novel agents showed outstanding effects in treatment of patients, often irrespective of their underlying genetic features.
Annika, Scheffold +2 more
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