Results 91 to 100 of about 98,172 (269)

Treatment of human pre-B acute lymphoblastic leukemia with the Aurora kinase inhibitor PHA-739358 (Danusertib)

Molecular Cancer, 2012
Background Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemias (Ph-positive ALL) with clinically approved inhibitors of the Bcr/Abl tyrosine kinase frequently results in the emergence of a leukemic clone carrying the T315I ...
Fei Fei, Lim Min, Schmidhuber Sabine, Moll Jürgen, Groffen John, Heisterkamp Nora   +5 more
doaj   +1 more source

Unraveling the complexity of tyrosine kinase inhibitor-resistant populations by ultra-deep sequencing of the BCR-ABL kinase domain.

Blood, 2013
In chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia, tyrosine kinase inhibitor (TKI) therapy may select for drug-resistant BCR-ABL mutants. We used an ultra-deep sequencing (UDS) approach to resolve qualitatively
S. Soverini, C. Benedittis, K. Polakova, A. Broučková, D. Horner, M. Iacono, F. Castagnetti, G. Gugliotta, F. Palandri, C. Papayannidis, I. Iacobucci, C. Venturi, M. Bochicchio, H. Klamová, F. Cattina, D. Russo, P. Bresciani, G. Binotto, B. Giannini, A. Kohlmann, T. Haferlach, A. Roller, G. Rosti, M. Cavo, M. Baccarani, G. Martinelli   +25 more
semanticscholar   +1 more source

Тактика выявления частых и редких типов химерного транскрипта BCR-ABL при хроническом миелоидном лейкозе

Клиническая онкогематология, 2015
Актуальность и цели. Диагноз хронического миелоидного лейкоза (ХМЛ) считается установленным при обнаружении транслокации t(9;22)(q34;q11) цитогенетическим методом и/или выявлении химерного транскрипта BCR-ABL методом полимеразной цепной реакции с ...
О. В. Никулина, Григорий Анатольевич Цаур, Т. О. Ригер, Ю. А. Яковлева, А. С. Демина, Е. Р. Семенихина, Т. В. Спильник, Л. И. Савельев, Л. Г. Фечина   +8 more
doaj   +1 more source

BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility

BMC Cancer, 2006
Background The reciprocal (9;22) translocation fuses the bcr (breakpoint cluster region) gene on chromosome 22 to the abl (Abelson-leukemia-virus) gene on chromosome 9.
Puccetti Elena, Beissert Tim, Güller Saskia, Zheng Xiaomin, Ruthardt Martin   +4 more
doaj   +1 more source

bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia [PDF]

, 1986
A De Klein, A Hagemeijer, CR Bartram, R Houwen, L Hoefsloot, F Carbonell, L Chan, M Barnett, M Greaves, E Kleihauer   +9 more
openalex   +1 more source

Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia.

Blood, 2013
The response of Philadelphia chromosome (Ph(+)) acute lymphoblastic leukemia (ALL) to treatment by BCR-ABL tyrosine kinase inhibitors (TKIs) has been disappointing, often resulting in short remissions typified by rapid outgrowth of drug-resistant clones.
B. Koss, J. Morrison, Rhonda M. Perciavalle, Harpreet Singh, J. Rehg, R. Williams, J. Opferman   +6 more
semanticscholar   +1 more source

Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis

Blood, 2008
Several RNA binding proteins (RBPs) have been implicated in the progression of chronic myelogenous leukemia (CML) from the indolent chronic phase to the aggressively fatal blast crisis. In the latter phase, expression and function of specific RBPs are aberrantly regulated at transcriptional or posttranslational levels by the constitutive kinase ...
Stefano Volinia, Stefano Volinia, Gustavo Leone, Mario Notari, Michael A. Caligiuri, William L. Willis, Ramasamy Santhanam, Guido Marcucci, Danilo Perrotti, Carlo Gambacorti-Passerini, Joshua J. Oaks, Ji Suk Chang, Anna M. Eiring, Paolo Neviani   +13 more
openaire   +6 more sources

Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism

BMC Cancer, 2012
Background Philadelphia positive leukemias are characterized by the presence of Bcr-Abl fusion protein which exhibits an abnormal kinase activity. Selective Abl kinase inhibitors have been successfully established for the treatment of Ph (+) leukemias ...
Khateb Mamduh, Ruimi Nili, Khamisie Hazem, Najajreh Yousef, Mian Afsar, Metodieva Anna, Ruthardt Martin, Mahajna Jamal   +7 more
doaj   +1 more source

Persistence of chronic myelocytic leukemia despite deletion of rearranged bcr/c-abl sequences in blast crisis. [PDF]

, 1986
Claus R. Bartram, Johannes W.G. Janssen, R. Becher, Annelies de Klein, Gerard C. Grosveld   +4 more
openalex   +1 more source

Targeting Primitive Chronic Myeloid Leukemia Cells by Effective Inhibition of a New AHI-1–BCR-ABL–JAK2 Complex

Journal of the National Cancer Institute, 2013
Background Imatinib mesylate (IM) induces clinical remission of chronic myeloid leukemia (CML). The Abelson helper integration site 1 (AHI-1) oncoprotein interacts with BCR-ABL and Janus kinase 2 (JAK2) to mediate IM response of primitive CML cells, but ...
Min Chen, P. Gallipoli, Donna DeGeer, I. Sloma, D. Forrest, M. Chan, Damian Lai, H. Jørgensen, Ashley Ringrose, Hui Wang, K. Lambie, Helen Nakamoto, Kyi Min Saw, A. Turhan, R. Arlinghaus, J. Paul, J. Stobo, M. Barnett, A. Eaves, C. Eaves, T. Holyoake, Xiaoyan Jiang   +21 more
semanticscholar   +1 more source