Results 81 to 90 of about 1,603 (142)

Genomic Landscape Analysis of Canine Pulmonary Adenocarcinoma Reveals Candidate Targetable Gene Fusions

Veterinary and Comparative Oncology, Volume 24, Issue 2, Page 393-406, June 2026.
ABSTRACT Spontaneously occurring primary canine pulmonary adenocarcinoma (cPAC) exhibits clinicopathological and molecular similarities to never‐smoker human lung cancers. Shared genomic alterations, including point mutations, indel mutations and copy number changes particularly in HER2 signalling, are significant therapeutic targets, especially for ...
Sharadha Sakthikumar, William P. D. Hendricks, David Rainford, William Selleck, Natalia Briones, Christopher Coggins, Natalie Quan, Victoria Zismann, Gwendolen Lorch, Aleksandar Sekulic, Jeffrey M. Trent   +10 more
wiley   +1 more source

Potential role of Notch signalling in CD34+ chronic myeloid leukaemia cells: cross-talk between Notch and BCR-ABL.

PLoS ONE, 2015
Notch signalling is critical for haemopoietic stem cell (HSC) self-renewal and survival. The role of Notch signalling has been reported recently in chronic myeloid leukaemia (CML) - a stem cell disease characterized by BCR-ABL tyrosine kinase activation.
Abdullah Aljedai, Anne-Marie Buckle, Prashant Hiwarkar, Farhatullah Syed   +3 more
doaj   +1 more source

Inhibition of BCR/ABL protein expression by miR-203 sensitizes for imatinib mesylate.

PLoS ONE, 2013
Selective inhibition of BCR/ABL expression by RNA interference has been demonstrated as an effective strategy in CML treatment and a reversal to imatinib resistance.
Yajuan Li, Ying Yuan, Kun Tao, Xin Wang, Qing Xiao, Zhenglan Huang, Liang Zhong, Weixi Cao, Jianping Wen, Wenli Feng   +9 more
doaj   +1 more source

Targeting HSPA8 to repress GPX4 and induce ferroptosis in BCR-ABL positive leukemia

Biomedical Technology
BCR-ABL positive (BCR-ABL+) leukemia is driven by constitutive activation of tyrosine kinase activity, with tyrosine kinase inhibitors (TKIs) serving as the standard treatment. However, resistance to TKIs remains a significant clinical challenge. In this
Shuxin Zhong, Dingrui Nie, Xueting Peng, Kangjie Qiu, Jinyi Liu, Zhangshuai Dai, Xianfeng Zha, Songnan Sui, Weini Li, Weizhang Wang, Cunte Chen, Yangqiu Li, Chengwu Zeng   +12 more
doaj   +1 more source

RAPSYN-mediated neddylation of BCR-ABL alternatively determines the fate of Philadelphia chromosome-positive leukemia

eLife
Philadelphia chromosome-positive (Ph+) leukemia is a fatal hematological malignancy. Although standard treatments with tyrosine kinase inhibitors (TKIs) have achieved remarkable success in prolonging patient survival, intolerance, relapse, and TKI ...
Mengya Zhao, Beiying Dai, Xiaodong Li, Yixin Zhang, Chun Qiao, Yaru Qin, Zhao Li, Qingmei Li, Shuzhen Wang, Yong Yang, Yijun Chen   +10 more
doaj   +1 more source

e8a2 BCR–ABL: more frequent than other atypical BCR–ABL variants? [PDF]

Leukemia, 2005
DEMEHRI S, PASCHKA P, SCHULTHEIS B, LANGE T, KOIZUMI T, SUGIMOTO T, BRANFORD S, LIM LC, KEGEL T, MARTINELLI, GIOVANNI, HOCHHAUS A, DRUKER BJ, DEININGER MW   +12 more
openaire   +2 more sources

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Chronic Myeloid Leukemia with Rare e1a3 BCR-ABL Transcript

Pakistan Journal of Medicine and Dentistry
Chronic myelogenous leukemia (CML) results from neoplastic transformation of a hematopoietic stem cell. It is cytogenetically characterized by the presence of Philadelphia chromosome which results from reciprocal translocation t(9;22) that juxtaposes ...
Najia Tabassum, Rubina Ghani, Mohammad Saboor, Moinuddin Moinuddin   +3 more
doaj  

BCR/ABL rearrangement and leukemia phenotype [PDF]

Leukemia, 1999
G, Saglio, F, Pane, G, Martinelli, A, Guerrasio   +3 more
openaire   +2 more sources