Results 101 to 110 of about 98,172 (269)

Application of chromosome microdissection probes for elucidation of BCR- ABL fusion and variant Philadelphia chromosome translocations in chronic myelogenous leukemia [PDF]

, 1993
Jianhao Zhang, Paul S. Meltzer, Ronald J. Jenkins, Xin–Yuan Guan, Jeffrey M. Trent   +4 more
openalex   +1 more source

Detection of chimeric BCR-ABL genes on bone marrow samples and blood smears in chronic myeloid and acute lymphoblastic leukemia by in situ hybridization [PDF]

, 1994
Martin Bentz, G Cabot, M Moos, MR Speicher, Arnold Ganser, Peter Lichter, H. Döhner   +6 more
openalex   +1 more source

Differential expression of miR-17∼92 identifies BCL2 as a therapeutic target in BCR-ABL-positive B-lineage acute lymphoblastic leukemia

Leukemia, 2013
Despite advances in allogeneic stem cell transplantation, BCR-ABL-positive acute lymphoblastic leukaemia (ALL) remains a high-risk disease, necessitating the development of novel treatment strategies.
M. Scherr, A. Elder, K. Battmer, D. Barzan, S. Bomken, M. Ricke-Hoch, A. Schro¨der, L. Venturini, H. Blair, J. Vormoor, O. Ottmann, A. Ganser, A. Pich, D. Hilfiker-Kleiner, O. Heidenreich, M. Eder   +15 more
semanticscholar   +1 more source

ABL single nucleotide polymorphisms may masquerade as BCR-ABL mutations associated with resistance to tyrosine kinase inhibitors in patients with chronic myeloid leukemia

Haematologica, 2008
The BCR-ABL K247R change is based on a rare single nucleotide polymorphism occurring likewise in healthy controls and non-hematologic cell types. Despite its juxtaposition to the P-loop, functional analysis showed no alteration compared to non-mutated ...
Thomas Ernst, Jana Hoffmann, Philipp Erben, Benjamin Hanfstein, Armin Leitner, Rüdiger Hehlmann, Andreas Hochhaus, Martin C. Müller   +7 more
doaj   +1 more source

BCR-ABL protein expression in peripheral blood cells of chronic myelogenous leukemia patients undergoing therapy [PDF]

, 1994
JQ Guo, JY Lian, YM Xian, MS Lee, AB Deisseroth, SA Stass, RE Champlin, Moshe Talpaz, Jiu‐Yao Wang, R B Arlinghaus   +9 more
openalex   +1 more source

Another tool in the BCR–ABL kit? [PDF]

Nature Reviews Cancer, 2011
This Cell paper shows that an interaction between the SH2 and kinase domains of BCR–ABL is necessary for kinase activation; inhibition of this interface prevents leukaemogenesis in mice and can restore sensitivity to tyrosine kinase inhibitors.
openaire   +3 more sources

Sphingomyelin synthase 1 activity is regulated by the BCR-ABL oncogene[S]

Journal of Lipid Research, 2013
Sphingomyelin synthase (SMS) produces sphingomyelin while consuming ceramide (a negative regulator of cell proliferation) and forming diacylglycerol (DAG) (a mitogenic factor). Therefore, enhanced SMS activity could favor cell proliferation.
Tara Ann Burns, Marimuthu Subathra, Paola Signorelli, Young Choi, Xiaofeng Yang, Yong Wang, Maristella Villani, Kapil Bhalla, Daohong Zhou, Chiara Luberto   +9 more
doaj  

BCR-ABL rearrangements in children with Philadelphia chromosome- positive chronic myelogenous leukemia [PDF]

, 1991
I Aurer, A Butturini, Gale Rp
openalex   +1 more source

BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia [PDF]

, 1993
A Bedi, BA Zehnbauer, MI Collector, James Barber, MS Zicha, SJ Sharkis, RJ Jones   +6 more
openalex   +1 more source

Controls for reverse transcriptase-polymerase chain reaction amplification of BCR-ABL transcripts [letter] [PDF]

, 1994
JV Melo, NS Kent, XH Yan, JM Goldman
openalex   +1 more source