Results 1 to 10 of about 232,503 (311)

Case report: BCR-ABL-positive acute lymphoblastic leukemia with bone destruction: a treatment dilemma [PDF]

Frontiers in Oncology
Although bone destruction and hypercalcemia without acute peripheral blast BCR-ABL-positive acute lymphoblastic leukemia (ALL) have been reported in children, they are rare in adults.
Shi Lijun, Ma Zhongrui, Ma Zhongrui, Wei Li, Yu Xia, Jiang Wei, Pan Yaning   +6 more
doaj   +6 more sources

Differential roles of STAT1 and STAT2 in the sensitivity of JAK2V617F- vs. BCR-ABL-positive cells to interferon alpha [PDF]

Journal of Hematology & Oncology, 2019
Background Interferon alpha (IFNa) monotherapy is recommended as the standard therapy in polycythemia vera (PV) but not in chronic myeloid leukemia (CML). Here, we investigated the mechanisms of IFNa efficacy in JAK2V617F- vs.
Claudia Schubert, Manuel Allhoff, Stefan Tillmann, Tiago Maié, Ivan G. Costa, Daniel B. Lipka, Mirle Schemionek, Kristina Feldberg, Julian Baumeister, Tim H. Brümmendorf, Nicolas Chatain, Steffen Koschmieder   +11 more
doaj   +3 more sources

Pterostilbene downregulates BCR/ABL and induces apoptosis of T315I-mutated BCR/ABL-positive leukemic cells [PDF]

Scientific Reports, 2022
In this study, we examined the antileukemic effects of pterostilbene, a natural methylated polyphenol analog of resveratrol that is predominantly found in berries and nuts, using various human and murine leukemic cells, as well as bone marrow samples ...
Shohei Kawakami, Mitsuyo Tsuma-Kaneko, Masakazu Sawanobori, Tomoko Uno, Yoshihiko Nakamura, Hideyuki Matsuzawa, Rikio Suzuki, Makoto Onizuka, Takashi Yahata, Kazuhito Naka, Kiyoshi Ando, Hiroshi Kawada   +11 more
doaj   +5 more sources

Tyrosine kinase inhibitors in BCR-ABL positive acute lymphoblastic leukemia. [PDF]

Haematologica, 2015
Philadelphia chromosome (Ph)/BCR/ABL-positive acute lymphoblastic leukemia (ALL) is the most common genetic abnormality associated with adult ALL and has been shown to confer the worst prognosis to both children and adults.[1][1],[2][2] Approximately 3 ...
Leoni V, Biondi A.
europepmc   +7 more sources

EPS8 regulates proliferation, apoptosis and chemosensitivity in BCR-ABL positive cells via the BCR-ABL/PI3K/AKT/mTOR pathway. [PDF]

Oncol Rep, 2018
Although the introduction of tyrosine kinase inhibitors greatly improved the survival of patients with chronic myeloid leukemia (CML), drug resistance remains a problem. Thus, mechanism-based novel therapeutic targets warrant exploration.
Huang R, Liu H, Chen Y, He Y, Kang Q, Tu S, He Y, Zhou X, Wang L, Yang J, Wu A, Li Y.   +11 more
europepmc   +5 more sources

The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib. [PDF]

PLoS One, 2012
Separase, an endopeptidase required for the separation of sister-chromatides in mitotic anaphase, triggers centriole disengagement during centrosome duplication. In cancer, separase is frequently overexpressed, pointing to a functional role as an aneuploidy promoter associated with centrosomal amplification and genomic instability.
Haaß W, Stehle M, Nittka S, Giehl M, Schrotz-King P, Fabarius A, Hofmann WK, Seifarth W.   +7 more
europepmc   +7 more sources

BCR/ABL positive thrombocythemia: a diagnostic dilemma

The Egyptian Journal of Internal Medicine, 2017
Both chronic myeloid leukemia and essential thrombocythemia are part of the spectrum of myeloproliferative neoplasm. Therefore, considerable overlap may occur in the clinical manifestations, and hematological and molecular findings in some patients.
Lubna Zafar, Feroz Alam, Anjum Parvez, Srikant Behera   +3 more
doaj   +4 more sources

In Vivo Eradication of Human BCR/ABL-Positive Leukemia Cells With an ABL Kinase Inhibitor [PDF]

JNCI: Journal of the National Cancer Institute, 1999
BACKGROUND The leukemia cells of approximately 95% of patients with chronic myeloid leukemia and 30%-50% of adult patients with acute lymphoblastic leukemia express the Bcr/Abl oncoprotein, which is the product of a fusion gene created by a chromosomal ...
Philipp le Coutre, Luca Mologni, Loredana Cleris, Edoardo Marchesi, Elisabeth Buchdunger, Roberto Giardini, Franca Formelli, Carlo Gambacorti‐Passerini   +7 more
semanticscholar   +6 more sources

Aleukemic bcr-abl positive granulocytic sarcoma [PDF]

Leukemia Research, 2009
Granulocytic sarcoma (GS) can occur de novo or in association with intramedullary myeloid disorders. With the advent of sophisticated molecular detection techniques to detect diagnostic genes such as bcr-abl, PML-RARA and CBFB/MYH11 in bone marrow or peripheral blood, many cases of the so called 'primary' GS are questionable.
Jew-Win Kuan, Pathmanathan Rajadurai, Kian-Meng Chang, Sen-Moi Tan   +3 more
openalex   +5 more sources

Imatinib spells BAD news for Bcr/abl-positive leukemias [PDF]

Proceedings of the National Academy of Sciences, 2006
One of the medical success stories of the past decade has been the development of new agents to treat chronic myelogenous leukemia (CML). Building on earlier studies that identified the t(9;22) chromosomal translocation in CML, cloned the BCR/ABL fusion gene, and demonstrated the ability of the resulting kinase to transform cells, investigators ...
Scott H. Kaufmann
openalex   +4 more sources