Results 1 to 10 of about 80,480 (249)
Asciminib for Philadelphia chromosome positive leukemias [PDF]
HaematologicaTwenty-five years after the introduction of imatinib, we have entered a new era of therapy for Chronic Myeloid Leukemia (CML). Despite the development of second and third generation (2G and 3G) tyrosine kinase inhibitors (TKIs), their impact have been ...
Timothy P. Hughes +2 more
doaj +4 more sources
The Philadelphia chromosome in leukemogenesis [PDF]
Chinese Journal of Cancer, 2016 The truncated chromosome 22 that results from the reciprocal translocation t(9;22)(q34;q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid leukemia (CML).
Zhi-Jie Kang +10 more
doaj +3 more sources
p185BCR/ABL has a lower sensitivity than p210BCR/ABL to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia [PDF]
Haematologica, 2012 Background The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the Philadelphia chromosome. The p185BCR/ABL or the p210BCR/ABL fusion proteins are encoded as a result
Afsar A. Mian +5 more
doaj +2 more sources
International Journal of Medical Students, 2015 Background: Treatment for adult Philadelphia chromosome+ acute lymphoblastic leukemia includes using dasatinib, a tyrosine kinase inhibitor. Cutaneous squamous cell carcinomas and keratoacanthomas are common findings in patients treated with BRAF ...
Siddhant Thukral +3 more
doaj +3 more sources
How I diagnose and manage Philadelphia chromosome-like acute lymphoblastic leukemia
Haematologica, 2019 Advances in our understanding of mechanisms of leukemogenesis and driver mutations in acute lymphoblastic leukemia (ALL) lead to a more precise and informative sub-classification, mainly of B-cell ALL. In parallel, in recent years, novel agents have been
Avraham Frisch, Yishai Ofran
doaj +3 more sources
A Case of Philadelphia Chromosome Positive Myeloproliferative Neoplasm in a Pregnant Woman with Unusual Primary Myelofibrosis Features [PDF]
Case Reports in Hematology, 2013 Myeloproliferative neoplasms (MPNs) are traditionally separated into BCR-ABL-positive chronic myeloid leukemia (CML), and BCR-ABL-negative MPNs including primary myelofibrosis (PMF), essential thrombocythemia (ET), and so forth.
Jason Koshy +4 more
doaj +2 more sources
Haematologica, 2007 Five Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML) patients with additional chromosome abnormalities at diagnosis have been followed during Imatinib therapy.
Alfonso Zaccaria +5 more
doaj +3 more sources
Prognostic implications of additional genomic lesions in adult Philadelphia chromosome-positive acute lymphoblastic leukemia [PDF]
Haematologica, 2019 To shed light onto the molecular basis of Philadelphia chromosome-positive acute lymphoblastic leukemia and to investigate the prognostic role of additional genomic lesions, we analyzed copy number aberrations using the Cytoscan HD Array in 116 newly ...
Anna Lucia Fedullo +18 more
doaj +2 more sources
Gomal Journal of Medical Sciences, 2017 Philadelphia (Ph’) chromosome is an abnormally short chromosome 22 formed as a result of translocation between chromosome 9 and 22. As a result the ABL gene from chromosome 9 joins the BCR gene on chromosome 22.
Habibullah Khan
doaj +1 more source
Philadelphia chromosome positive AML arising from JAK2-positive myelofibrosis
Biomarker Research, 2018 Background A feature of myeloproliferative neoplasia is transforming to more aggressive and malignant myeloid neoplasia, including acute myeloid leukemia.
Marte Karen Brattås +8 more
doaj +2 more sources