Results 31 to 40 of about 80,480 (249)

Evaluation of Common Genetic Disorders in Myeloproliferative Neoplasms [PDF]

International Journal of Hematology-Oncology and Stem Cell Research, 2011
Introduction: The myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by excessive production of blood cells by  hematopoietic precursors. Typically, they include polycythemia vera (PV), essential thrombocythemia (ET),
Mehrdad Payandeh, Farhad Shaveisi Zadeh, Mohammad Erfan Zare, Kamran Mansouri, Reza Khodarahmi, Saeed Alimoradi, Hoshang Yousefi, Fatemeh Darabi   +7 more
doaj   +1 more source

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I [PDF]

, 2012
Background: Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (Ph + ALL) are caused by the t(9;22), which fuses BCR to ABL resulting in deregulated ABL-tyrosine kinase activity.
Ruimi, Nili, Martin Ruthardt, Mahajna, Jamal, Khateb, Mamduh, Jamal Mahajna, Ruthardt, Martin, Ottmann, Oliver G., Oliver Gerhard Ottmann, Mian, Afsar Ali, Nili Ruimi, Yousef Najajreh, Afsar Ali Mian, Ottmann, Oliver Gerhard, Susanne Badura, Metodieva, Anna, Najajreh, Yousef, Anna Metodieva, Mamduh Khateb, Badura, Susanne   +18 more
core   +1 more source

Bilateral Serous Retinal Detachment in Lymphoid Blast Crisis of Chronic Myeloid Leukemia

Case Reports in Ophthalmology, 2021
We herein report a patient with Philadelphia chromosome-positive lymphoid blast crisis of chronic myeloid leukemia (CML), who presented with bilateral serous retinal detachment (SRD).
Kyohei Umemura, Kyoko Fujita, Akiko Jinno, Ayano Nakamura, Motohiro Kamei   +4 more
doaj   +1 more source

Reduced‐intensity therapy for relapsed Philadelphia chromosome‐positive leukemia [PDF]

, 2023
Citation: Shun Nagasawa, Ai Yamada, Midori Nakagawa, Mariko Kinoshita, Yuhki Koga, Shouichi Ohga, Hiroshi Moritake, Reduced‐intensity therapy for relapsed Philadelphia chromosome‐positive leukemia, Pediatric Blood & Cancer, 71(2), 2023-12-05, https://doi.
Kinoshita, Mariko, Koga, Yuhki, ナガサワ, シュン, Nakagawa, Midori, 永澤, 俊, Nagasawa, Shun, 35493, 40336300, Moritake, Hiroshi, ヤマダ, アイ, Ohga, Shouichi, 28692, 35312, モリタケ, ヒロシ, Yamada, Ai, 山田, 愛, 90816688, 盛武, 浩   +17 more
core  

Pediatric Philadelphia-positive B lymphoblastic leukemia with CD56 expression and L2 morphology: Case report and review of the literature

Human Pathology: Case Reports, 2017
We present a unique case of pediatric B lymphoblastic leukemia with Philadelphia chromosome, CD56 expression, and predominantly L2 morphology. A review of the current literature demonstrates that this distinct combination of features is rare and may ...
Jadee Neff, MD, PhD, Dong Chen, MD, PhD
doaj   +1 more source

Philadelphia chromosome-positive pre-B lymphoblastic leukemia presenting as acute hepatic failure in a pediatric patient

, 2021
Philadelphia chromosome-positive pre-B lymphoblastic leukemia presenting as acute hepatic failure in a pediatric ...
ZoAnn E. Dreyer (11856584), Valeria Smith (11856581), Kalyani R. Patel (11856578), Alexis K. Williams (11856575), Rohit Gupta (2642632), Andrea N. Marcogliese (10577019)   +5 more
core   +1 more source

Applying the discovery of the Philadelphia chromosome [PDF]

Journal of Clinical Investigation, 2007
The identification of the Philadelphia chromosome in cells from individuals with chronic myelogenous leukemia (CML) led to the recognition that the BCR-ABL tyrosine kinase causes CML. This in turn led to the development of imatinib mesylate, a clinically successful inhibitor of the BCR-ABL kinase.
Daniel W, Sherbenou, Brian J, Druker
openaire   +2 more sources

Avaliação de parâmetros laboratoriais e clínicos de pacientes portadores de leucemia mielóide crônica submetidos ao tratamento com mesilato de imatinibe e sua relação com alterações observadas no estroma da medula óssea Correlation between laboratory and clinical parameters of chronic myeloid leukemia patients treated with imatinib mesylate and its relationship with stromal changes observed in bone marrow biopsy [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-graduação em FarmáciaA leucemia mieloide cronica (LMC) e uma doenca mieloproliferativa clonal, responsavel por 14% de todos os casos de ...
Caroline R. de Jesus, Jesus, Caroline Regina de   +1 more
core   +1 more source

"Transformation of chronic myelogenous leukemia to Multiple Myeloma: A case report " [PDF]

Acta Medica Iranica, 2003
Chronic myelogenous leukemia (CML) is a stem cell disorder sometimes associated with lymphoproliferative disorders. CML may precede a lymphoproliferative disorder.
"Ghavamzadeh A, Alimoghaddam K, Mehdipour P, Sharifian R, Schwanitz G, Shamshiri AR "   +5 more
doaj   +1 more source

A unique three-way Philadelphia chromosome variant t(4;9;22)(q21;q34;q11.2) in a newly diagnosed patient with chronic phase chronic myeloid leukemia: a case report and review of the literature

Journal of Medical Case Reports, 2021
Background Chronic myeloid leukemia is a hematologic malignancy associated with the fusion of two genes: BCR and ABL1. This fusion results from a translocation between chromosomes 9 and 22, which is called the Philadelphia chromosome.
Yuka Torii, Kana Nanjo, Tomomi Toubai, Masashi Hosokawa, Ryo Sato, Akane Yamada, Keiko Aizawa, Masahito Himuro, Satoshi Ito, Masakazu Yamamoto, John Magenau, Ryan Wilcox, Kenichi Ishizawa   +12 more
doaj   +1 more source