Results 11 to 20 of about 76,188 (198)
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Frontiers in Genetics, 2022 We aim to determine the spectrum of cytogenetic abnormalities and outcomes in unbalanced offspring of asymptomatic constitutional balanced t(9;22) carriers through a systematic literature review. We also include a case of a constitutional balanced t(9;22)
Zimeng Gao +8 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 1999 We have investigated a single telomere expansion in a case of acute lymphoblastic B-cell leukemia (B-ALL), where half of the cells in the bone marrow sample appeared with a Philadelphia chromosome. Comparing telomere sizes in Philadelphia-positive versus
Katerina Krejcí +2 more
doaj +1 more source
Response to “Philadelphia chromosome?” [PDF]
American Journal of Hematology, 2006 WOS ...
openaire +2 more sources
How I diagnose and manage Philadelphia chromosome-like acute lymphoblastic leukemia
Haematologica, 2019 Advances in our understanding of mechanisms of leukemogenesis and driver mutations in acute lymphoblastic leukemia (ALL) lead to a more precise and informative sub-classification, mainly of B-cell ALL. In parallel, in recent years, novel agents have been
Avraham Frisch, Yishai Ofran
doaj +1 more source
Bilateral Serous Retinal Detachment in Lymphoid Blast Crisis of Chronic Myeloid Leukemia
Case Reports in Ophthalmology, 2021 We herein report a patient with Philadelphia chromosome-positive lymphoid blast crisis of chronic myeloid leukemia (CML), who presented with bilateral serous retinal detachment (SRD).
Kyohei Umemura +4 more
doaj +1 more source
Evaluation of Common Genetic Disorders in Myeloproliferative Neoplasms [PDF]
International Journal of Hematology-Oncology and Stem Cell Research, 2011 Introduction: The myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by excessive production of blood cells by hematopoietic precursors. Typically, they include polycythemia vera (PV), essential thrombocythemia (ET),
Mehrdad Payandeh +7 more
doaj +1 more source
Human Pathology: Case Reports, 2017 We present a unique case of pediatric B lymphoblastic leukemia with Philadelphia chromosome, CD56 expression, and predominantly L2 morphology. A review of the current literature demonstrates that this distinct combination of features is rare and may ...
Jadee Neff, MD, PhD, Dong Chen, MD, PhD
doaj +1 more source
Haematologica, 2012 Background The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the Philadelphia chromosome. The p185BCR/ABL or the p210BCR/ABL fusion proteins are encoded as a result
Afsar A. Mian +5 more
doaj +1 more source
Applying the discovery of the Philadelphia chromosome [PDF]
Journal of Clinical Investigation, 2007 The identification of the Philadelphia chromosome in cells from individuals with chronic myelogenous leukemia (CML) led to the recognition that the BCR-ABL tyrosine kinase causes CML. This in turn led to the development of imatinib mesylate, a clinically successful inhibitor of the BCR-ABL kinase.
Daniel W, Sherbenou, Brian J, Druker
openaire +2 more sources