Results 11 to 20 of about 80,480 (249)

Umbilical cord blood transplantation from unrelated donors in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia

open access: yesHaematologica, 2014
There are very few disease-specific studies focusing on outcomes of umbilical cord blood transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia.
José Luis Piñana   +15 more
doaj   +3 more sources

Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation [PDF]

open access: yesCase Reports in Oncology, 2013
Acute lymphoblastic leukemia (ALL) is a cancer of the white blood cells and is typically well treated with combination chemotherapy, with a remission state after 5 years of 94% in children and 30-40% in adults. To establish how aggressive the disease is,
Yadvinder Singh, Chamandeep Bali
doaj   +2 more sources

A case of leukemia cutis showing annular erythema during the course of Philadelphia chromosome‐positive acute B‐lymphoblastic leukemia

open access: yesClinical Case Reports
Key Clinical Message We report a case of leukemia cutis showing annular erythema during the course of Philadelphia chromosome‐positive acute B‐lymphoblastic leukemia. The annular appearance may be developed by immunomodulatory effects of blinatumomab.
Hizuru Tomita   +6 more
doaj   +2 more sources

Chromosomal Aberrations in Chronic Myeloid Leukemia: Response to Conventional TKIs and Risk of Blastic Transformation

open access: yesAsian Pacific Journal of Cancer Care, 2021
Background and Purpose: Chronic Myeloid Leukemia (CML) is a common hematological malignancy. The characteristic molecular abnormality is the presence of Philadelphia chromosome or BCR-ABL fusion gene which is the result of 9:22 translocation.
Shafaq Maqsood   +3 more
doaj   +1 more source

A case of acute lymphoblastic leukemia with additional chromosomes X and 5 associated with a Philadelphia chromosome in the bone marrow

open access: yesTurkish Journal of Hematology, 2010
We report herein a very rare case of acute lymphoblastic leukemia having a chromosomal constitution of 48,XY,+X,+5,t(9;22)(q34;q11) in the bone marrow.
Burak Durmaz   +5 more
doaj   +3 more sources

The legacy of the Philadelphia chromosome [PDF]

open access: yesJournal of Clinical Investigation, 2007
The discovery of the Philadelphia chromosome as a hallmark of chronic myelogenous leukemia in 1960 by Peter Nowell provided evidence for a genetic link to cancer. As with most seminal scientific observations, the description of the Philadelphia chromosome posed many more questions than were answered.
openaire   +2 more sources

Diversity of breakpoints of variant Philadelphia chromosomes in chronic myeloid leukemia in Brazilian patients

open access: yesRevista Brasileira de Hematologia e Hemoterapia, 2015
Background: Chronic myeloid leukemia is a myeloproliferative disorder characterized by the Philadelphia chromosome or t(9;22)(q34.1;q11.2), resulting in the break-point cluster regionAbelson tyrosine kinase fusion gene, which encodes a constitutively ...
Maria de Lourdes Lopes Ferrari Chauffaille   +2 more
doaj   +1 more source

JAK2-V617F Mutation Combined with Philadelphia Chromosome-Positive Chronic Myeloid Leukaemia: a Case Report [PDF]

open access: yesInternational Journal of Hematology-Oncology and Stem Cell Research, 2011
Myeloproliferative neoplasms (MPNs) such as polycythemia vera, essential thrombocythemia, primary myelofibrosis and chronic myeloid leukemia have too similar and accurate way to differentiate their is study of genetic disorders in these patients ...
Mehrdad Payande   +3 more
doaj   +1 more source

Marrow fibrosis associated with a Philadelphia chromosome [PDF]

open access: yes, 1992
Three patients had marked marrow fibrosis and an apparent Philadelphia (Ph) chromosome. Hematologic, cytogenetic, and molecular studies demonstrated the heterogeneity of such cases, including the first example of clinically typical myelofibrosis (MF ...
Nowell, Peter C.   +4 more
core   +1 more source

Acute Lymphoblastic Leukemia Without the Philadelphia Chromosome Occurring in Chronic Myelogenous Leukemia With the Philadelphia Chromosome

open access: yes, 2021
The blast crisis in chronic myelogenous leukemia (CML) is related to the evolution of a Philadelphia chromosome (Ph)-positive clone. Secondary chromosomal abnormalities accompanied by t(9;22) are found in 70-80% of blast crises.
정화순   +3 more
core   +1 more source

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