Pterostilbene downregulates BCR/ABL and induces apoptosis of T315I-mutated BCR/ABL-positive leukemic cells [PDF]
Scientific Reports, 2022 In this study, we examined the antileukemic effects of pterostilbene, a natural methylated polyphenol analog of resveratrol that is predominantly found in berries and nuts, using various human and murine leukemic cells, as well as bone marrow samples ...
Shohei Kawakami +11 more
doaj +5 more sources
BCR/ABL positive thrombocythemia: a diagnostic dilemma
The Egyptian Journal of Internal Medicine, 2017 Both chronic myeloid leukemia and essential thrombocythemia are part of the spectrum of myeloproliferative neoplasm. Therefore, considerable overlap may occur in the clinical manifestations, and hematological and molecular findings in some patients.
Lubna Zafar +3 more
doaj +4 more sources
Efficacy and Pharmacologic Data of Second-Generation Tyrosine Kinase Inhibitor Nilotinib in BCR-ABL-Positive Leukemia Patients with Central Nervous System Relapse after Allogeneic Stem Cell Transplantation [PDF]
BioMed Research International, 2014 Central nervous system (CNS) involvement is a severe complication of BCR-ABL-positive leukemia after allogenic stem cell transplantation (alloSCT) associated with fatal outcome.
Mark Reinwald +12 more
openalex +2 more sources
Combination of the ABL kinase inhibitor imatinib with the Janus kinase 2 inhibitor TG101348 for targeting residual BCR-ABL-positive cells [PDF]
Journal of Hematology & Oncology, 2014 BackgroundThe ABL kinase inhibitor imatinib is highly effective in treating most, but not all, patients with chronic myeloid leukemia (CML). This is because residual CML cells are generally present in the bone marrow microenvironment and are refractory ...
Seiichi Okabe +4 more
openalex +2 more sources
Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia [PDF]
EMBO Molecular Medicine, 2010 Tumourigenesis caused by the Bcr/Abl oncoprotein is a multi‐step process proceeding from initial to tumour‐maintaining events and finally results in a complex tumour‐supporting network. A key to successful cancer therapy is the identification of critical
Andrea Hoelbl +14 more
semanticscholar +4 more sources
Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive Leukemias [PDF]
Advances in Hematology, 2015 BCR-ABL-mediated leukemias, either Chronic Myeloid Leukemia (CML) or Philadelphia positive Acute Lymphoblastic Leukemia (ALL), are the paradigm of targeted molecular therapy of cancer due to the impressive clinical responses obtained with BCR-ABL ...
Alessandro Morotti +6 more
doaj +5 more sources
BCR-ABL Positive Childhood Chronic Myeloid Leukemia
Journal of Case Reports, 2017 Background : Chronic myeloid leukemia (CML) is a rare disease entity in the pediatric age group constituting about 3-5% of childhood leukemia. The natural history and biologic characteristics of the disease are similar to adult CML.
T. Ekwere, E. Abudu
semanticscholar +4 more sources
An unusual case of T-cell acute lymphoblastic leukemia in a patient with BCR-ABL positive chronic myeloid leukemia and Gaucher disease. [PDF]
Ann Med Surg (Lond), 2021 Al-Janazreh H +7 more
europepmc +2 more sources
In Vivo Eradication of Human BCR/ABL-Positive Leukemia Cells With an ABL Kinase Inhibitor [PDF]
Journal of the National Cancer Institute, 1999 BACKGROUND The leukemia cells of approximately 95% of patients with chronic myeloid leukemia and 30%-50% of adult patients with acute lymphoblastic leukemia express the Bcr/Abl oncoprotein, which is the product of a fusion gene created by a chromosomal ...
Philipp le Coutre +7 more
openalex +2 more sources
Aleukemic bcr-abl positive granulocytic sarcoma [PDF]
Leukemia Research, 2009 Granulocytic sarcoma (GS) can occur de novo or in association with intramedullary myeloid disorders. With the advent of sophisticated molecular detection techniques to detect diagnostic genes such as bcr-abl, PML-RARA and CBFB/MYH11 in bone marrow or peripheral blood, many cases of the so called 'primary' GS are questionable.
Jew-Win Kuan +3 more
openalex +5 more sources