Results 11 to 20 of about 45,526 (248)
BCR/ABL positive thrombocythemia: a diagnostic dilemma
The Egyptian Journal of Internal Medicine, 2017 Both chronic myeloid leukemia and essential thrombocythemia are part of the spectrum of myeloproliferative neoplasm. Therefore, considerable overlap may occur in the clinical manifestations, and hematological and molecular findings in some patients.
Lubna Zafar +3 more
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Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive Leukemias [PDF]
Advances in Hematology, 2015 BCR-ABL-mediated leukemias, either Chronic Myeloid Leukemia (CML) or Philadelphia positive Acute Lymphoblastic Leukemia (ALL), are the paradigm of targeted molecular therapy of cancer due to the impressive clinical responses obtained with BCR-ABL ...
Alessandro Morotti +6 more
doaj +4 more sources
Philadelphia Chromosome-negative, bcr/abl-positive Chronic Myelogenous Leukemia.
Journal of Nippon Medical School, 2001 Koiti Inokuchi, Kazuo Dan
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BCR-ABL Positive Childhood Chronic Myeloid Leukemia
Journal of Case Reports, 2017 Timothy Ekwere, Emmanuel Kunle Abudu
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Environment-mediated drug resistance in Bcr/Abl-positive acute lymphoblastic leukemia [PDF]
OncoImmunology, 2012 Although cure rates for acute lymphoblastic leukemia (ALL) have increased, development of resistance to drugs and patient relapse are common. The environment in which the leukemia cells are present during the drug treatment is known to provide significant survival benefit.
Niklas Feldhahn +8 more
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Aleukemic bcr-abl positive granulocytic sarcoma [PDF]
Leukemia Research, 2009 Granulocytic sarcoma (GS) can occur de novo or in association with intramedullary myeloid disorders. With the advent of sophisticated molecular detection techniques to detect diagnostic genes such as bcr-abl, PML-RARA and CBFB/MYH11 in bone marrow or peripheral blood, many cases of the so called 'primary' GS are questionable.
Kuan, Jew-Win +3 more
openaire +3 more sources
Di-san junyi daxue xuebao, 2021 Objective To investigate the laboratory and clinical characteristics of acute lymphoblastic leukemia (ALL) with e1a3 BCR-ABL fusion protein. Methods The clinical data, and results of bone marrow cytology, flow cytometry, karyotyping, fluorescence in situ
CHEN Siyu +6 more
doaj +1 more source
The functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome-positive acute lymphatic leukemia. [PDF]
PLoS Genetics, 2015 The hallmark of Philadelphia chromosome positive (Ph(+)) leukemia is the BCR/ABL kinase, which is successfully targeted by selective ATP competitors. However, inhibition of BCR/ABL alone is unable to eradicate Ph(+) leukemia.
Anahita Rafiei +8 more
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Molecular Cancer, 2022 Background Dysregulation of long noncoding RNAs (lncRNAs) has been linked to various human cancers. Bcr-Abl oncogene that results from a reciprocal translocation between human chromosome 9 and 22, is associated with several hematological malignancies ...
Yun Ma +7 more
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Tyrosine kinase inhibitors in BCR-ABL positive acute lymphoblastic leukemia. [PDF]
Haematologica, 2015 Philadelphia chromosome (Ph)/BCR/ABL-positive acute lymphoblastic leukemia (ALL) is the most common genetic abnormality associated with adult ALL and has been shown to confer the worst prognosis to both children and adults.[1][1],[2][2] Approximately 3%–5% children and 25%–40% adults with ...
Leoni V, Biondi A.
europepmc +5 more sources