Results 21 to 30 of about 68,946 (284)

Impending Cardiac Tamponade as the Initial Manifestation of BCR-ABL Positive Chronic Myeloid Leukemia. [PDF]

Cureus, 2020
Moursy S, Gaballa S, Ahmed A, Hlaing KM, Patel BB.   +4 more
europepmc   +3 more sources

Imatinib spells BAD news for Bcr/abl-positive leukemias [PDF]

Proceedings of the National Academy of Sciences, 2006
One of the medical success stories of the past decade has been the development of new agents to treat chronic myelogenous leukemia (CML). Building on earlier studies that identified the t(9;22) chromosomal translocation in CML, cloned the BCR/ABL fusion gene, and demonstrated the ability of the resulting kinase to transform cells, investigators ...
Scott H. Kaufmann
openalex   +4 more sources

Targeted Degradation of SOS1 Exhibits Potent Anticancer Activity and Overcomes Resistance in KRAS-Mutant Tumors and BCR-ABL-Positive Leukemia. [PDF]

Cancer Res
Luo Z, Lin C, Yu C, Yuan C, Wu W, Xu X, Sun R, Jia Y, Wang Y, Shen J, Wang D, Wang S, Jiang H, Jiang B, Yang X, Xie C.   +15 more
europepmc   +2 more sources

BCR-ABL rearrangements in children with Philadelphia chromosome- positive chronic myelogenous leukemia [PDF]

Blood, 1991
Abstract Leukemia cells from adults with Philadelphia (Ph1)-chromosome positive chronic myelogenous leukemia (CML) have a characteristic molecular rearrangement between the BCR and ABL genes whereby major breakpoint cluster region (Mbcr) exons 2 or 3 are joined to ABL exon II.
I Aurer, A Butturini, Gale Rp
openalex   +5 more sources

Co-Occurrence of Jak2-Positive Myelofibrosis and Bcr-Abl-Positive Chronic Myelogenous Leukaemia Treated with Combination of Tyrosine Kinase Inhibitors and Ruxolitinib. [PDF]

Mediterr J Hematol Infect Dis
Paciaroni K, Campagna S, Villiva N, Maffini E, Celesti F, Tordi A, Lombardi M, Dragonetti G, di Toritto TC.   +8 more
europepmc   +2 more sources

Philadelphia Chromosome-negative, bcr/abl-positive Chronic Myelogenous Leukemia.

Journal of Nippon Medical School, 2001
Koiti Inokuchi, Kazuo Dan
openalex   +5 more sources

c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia. [PDF]

Biomark Res, 2016
Prinzhorn W, Stehle M, Kleiner H, Ruppenthal S, Müller MC, Hofmann WK, Fabarius A, Seifarth W.   +7 more
europepmc   +2 more sources

Retraction Note: Disruption of the Bcr-Abl/Hsp90 protein complex: a possible mechanism to inhibit Bcr-Abl-positive human leukemic blasts by novobiocin. [PDF]

Leukemia, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Wu LX, Xu JH, Zhang KZ, Lin Q, Huang XW, Wen CX, Chen YZ.   +6 more
europepmc   +4 more sources

The Proteolytic Activity of Separase in BCR-ABL-Positive Cells Is Increased by Imatinib

PLoS ONE, 2012
Separase, an endopeptidase required for the separation of sister-chromatides in mitotic anaphase, triggers centriole disengagement during centrosome duplication. In cancer, separase is frequently overexpressed, pointing to a functional role as an aneuploidy promoter associated with centrosomal amplification and genomic instability.
Wiltrud Haaß, Michael Stehle, Stefanie Nittka, Michelle Giehl, Petra Schrotz‐King, Alice Fabarius, Wolf‐Karsten Hofmann, Wolfgang Seifarth   +7 more
openalex   +6 more sources

Grb10 is involved in BCR-ABL-positive leukemia in mice [PDF]

Leukemia, 2014
The SH2-containing adaptor protein Grb10 was first identified in a yeast screen as a new binding partner for BCR-ABL and associates with BCR-ABL in a tyrosine-dependent manner. However, its function in BCR-ABL-mediated leukemogenesis in vivo is still unknown.
A. Illert, C. Albers, S. Kreutmair, H. Leischner, C. Peschel, C. Miething, J. Duyster   +6 more
semanticscholar   +5 more sources