Results 151 to 160 of about 290,825 (294)

Biphasic Effects on Allergen‐Specific Type 2 Memory B Cells Over 18 Months Sublingual Immunotherapy for House Dust Mite Allergy

Allergy, EarlyView.
Rapid clinical relief of allergy symptoms during 18 months of sublingual immunotherapy (SLIT) for house dust mite (HDM) is associated with increased serum IgE, IgG2, and IgG4 to Der p 1 and Der p 2. Der p 1 and Der p 2 specific Type 2 memory B cells are expanded at 4 months and 12 months of SLIT, with increased expression of CD29 and IgG4.
Lin Hsin, Simone Reinwald, Anouk von Borstel, Pei Mun Aui, Kirsten Deckert, P. Mark Hogarth, Laurent Mascarell, Mark Hew, Robyn E. O'Hehir, Menno C. van Zelm   +9 more
wiley   +1 more source

SHIP-1 adapter functions mediate recruitment of FCRL1 to the BCR and inhibition of ERK. [PDF]

Immunohorizons
Wolfe MM, Tallon Arranz R, Zenni EL, Wilson TJ.   +3 more
europepmc   +1 more source

School achievement in the Brazilian rural Amazon: An analysis of the interaction among motor, cognitive and environmental factors

British Journal of Developmental Psychology, EarlyView.
Abstract A cross‐sectional study of 106 students (7–12 years) from a rural school in the Brazilian Amazon investigated the interaction among motor, cognitive and environmental factors on school achievement using network analysis. Students with good school performance were significantly older and showed superior global physical fitness, motor ...
Douglas Vieira, Cinthia Rodrigues Barros, Mabliny Thuany, Thayse Natacha Gomes   +3 more
wiley   +1 more source

Testosterone-Sparing Treatment Strategies for Biochemically Recurrent Prostate Cancer After Radical Prostatectomy. [PDF]

Curr Oncol Rep
Najdawi F, Sayyid RK, Ahlering T, Lee DI, Dobbs RW, Shahait M.   +5 more
europepmc   +1 more source

MIZ-1 controls transcriptional programs required for BCR signaling, actin dynamics, and naïve B cell survival. [PDF]

Front Immunol
Ross J, Piskor EM, Joly-Beauparlant C, Tabarez LPG, El Ghorayeb E, Droit A, Kosan C, Möröy T.   +7 more
europepmc   +1 more source

AI-Driven BCR Modeling for Precision Immunology. [PDF]

Int J Mol Sci
Liu T, Zhao X, Yang F.
europepmc   +1 more source

Introducing a prognostic score for successful treatment‐free remission in chronic myeloid leukaemia

British Journal of Haematology, EarlyView.
Summary The modern management of chronic myeloid leukaemia (CML) identifies a new therapeutic goal of treatment‐free remission (TFR). Half of CML patients in durable deep molecular response (DMR) (MR4 or better) can remain off tyrosine kinase inhibitors (TKIs) without experiencing loss of major molecular response.
Simone Claudiani, Silvia Metelli, Afzal Khan, Guy Hannah, Jenny Byrne, Paolo Gallipoli, Simon J. Bulley, Gillian A. Horne, Kate Rothwell, Mhairi Copland, Richard E. Clark, Fiona Fernando, Andrew J. Innes, Jane F. Apperley, Dragana Milojkovic   +14 more
wiley   +1 more source

Chemotherapy‐driven expression of WNT ligands in bone marrow stromal cells contributes to chemoresistance in acute lymphoblastic leukaemia

British Journal of Haematology, EarlyView.
Chemotherapy‐induced WNT ligand secretion by bone marrow (BM) stroma drives acute lymphoblastic leukaemia (ALL) chemoresistance. WNT pathway inhibition disrupts this cross‐talk and restores therapeutic response, highlighting WNT inhibitors as a promising strategy to prevent relapse in ALL.
Foteini Kalampalika, Amanda Jiménez‐Pompa, Raúl Sánchez‐Lanzas, Bela Patel, Miguel Ganuza   +4 more
wiley   +1 more source

Targeting leukemic stem and progenitor cells expressing different BCR::ABL1 levels: antileukemic activity of asciminib with or without TKIs. [PDF]

Front Pharmacol
Massimino M, Tirrò E, Romano C, Stella S, Tomarchio C, Vitale SR, Manzella L, Di Raimondo F, Stagno F, Vigneri P.   +9 more
europepmc   +1 more source

MicroRNAs as potential architects of immune dysregulation and megakaryocytic failure in immune thrombocytopenia

British Journal of Haematology, EarlyView.
Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu, Johan Rebetz, Lamya Garabet, Waleed Ghanima, Peipei Xu, Hans Wadenvik, Drew Provan, Rick Kapur, John W. Semple   +8 more
wiley   +1 more source