Results 161 to 170 of about 122,805 (310)

Significant association of BDNF rs6265 G>A polymorphism with susceptibility to epilepsy: a meta-analysis

, 2018
Yue-Long Xu,1,* Xiu-Xiu Li,1,* Su-Jing Zhuang,1 Shi-Feng Guo,1 Jian-Ping Xiang,1 Long Wang,2 Lan Zhou,2 Bin Wu3 1Department of Neurology, Linyi Central Hospital, Linyi 276400, Shandong Province, China; 2Department of Neurology, Center for Evidence-Based
Li X, Zhou L, Zhuang S, Xiang J, Wu B, Guo S, Xu Y, Wang L   +7 more
core  

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

A study of neuroprotective effect stereospecificity of dipeptide mimetic of the Brain-derived neurotrophic factor GSB-106 on the model oxidative stress in the culture hippocampal cell line HT-22

Фармакокинетика и Фармакодинамика, 2017
In the present work, the neuroprotective effect stereospecificity of dimeric dipeptide mimetic of the 4th loop of BDNF-GSB-106 is studied. Activity of its diastereomers GT-106DL (hexamethylenediamide bis-monosuccinyl-D-seryl-L-lysine) and GT-106LD ...
I. O. Logvinov, A. V. Tarasiuk, P. I. Antipov, T. A. Antipova   +3 more
doaj  

Effects of transcranial direct current stimulation on pain and function in patients with knee osteoarthritis: A systematic review and meta‐analysis

PM&R, EarlyView.
Abstract Objective The aim of this systematic review and meta‐analysis is to determine the effects of transcranial direct current stimulation (TDCS) on pain (considering the different types of pain measured) and function in adults with knee osteoarthritis (OA).
Noemí Moreno‐Segura, Sara Mollà‐Casanova, Elena Muñoz‐Gómez, Marta Inglés, Pilar Serra‐Añó   +4 more
wiley   +1 more source

Influence of the Brain-Derived Neurotrophic Factor Gene Polymorphism on Weight Loss Following Intragastric Balloon Intervention: A Cross-Sectional Study

Diabetes, Metabolic Syndrome and Obesity
Ahmad Al-Serri,1 Hessa A Al-Janahi,1 Mohammad H Jamal,2 Dana AlTarrah,3 Ali H Ziyab,4 Suzanne A Al-Bustan5 1Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait; 2Department of Surgery, Faculty of Medicine, Kuwait ...
Al-Serri A, Al-Janahi HA, Jamal MH, AlTarrah D, Ziyab AH, Al-Bustan SA   +5 more
doaj  

Cognitive dysfunction and epigenetic alterations at the BDNF gene are induced by social isolation during early adolescence

, 2016
Early life adversity, such as social isolation, causes a variety of changes to the development of cognitive abilities and the nervous system. Increasing evidence has shown that epigenetic modifications mediate gene-environment interactions ...
Wei Du, W. Wang, F. Shao, Weiwen Wang, Feng Shao, Man Li   +5 more
core  

Stem cell–mediated neuroplasticity and psychological recovery in cancer survivors: Mechanisms, evidence, and translational challenges

Precision Medical Sciences, EarlyView.
Cancer therapies can trigger neuroinflammation and disrupted neuroplasticity, contributing to cognitive impairment and psychological distress in survivors. Stem cells (NSCs/MSCs) and their extracellular vesicles may restore neural niches via trophic support, immunomodulation, synaptic remodeling, and vascular repair, but require rigorous safety, dosing,
Xinyi Yang
wiley   +1 more source

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, EarlyView.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

Role of BDNF in form-deprivation myopia progression in guinea pigs. [PDF]

Front Immunol
Xie RY, Wang Q, Liu H, Luo R, Liu CY, Li S, Chai Y, Xiong F.   +7 more
europepmc   +1 more source