Results 141 to 150 of about 122,805 (310)

Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence

, 2016
Early life adversity, such as social isolation, causes a variety of changes to the development of cognitive abilities and the nervous system. Increasing evidence has shown that epigenetic modifications mediate gene-environment interactions throughout the
Wang, Weiwen, Shao, Feng, Li, Man, Du, Wei   +3 more
core   +1 more source

Roles of histone lysine methylation in neurodevelopment and related disorders

Ibrain, EarlyView.
This graphical abstract centers on the theme of dynamic balance and systematically outlines the role of histone lysine methylation in neurodevelopment and related disorders. The figure first presents two key classes of regulators that control this balance—“writers” and “erasers”—and then indicates how interactions among different epigenetic ...
Yun Chen, Yi Zhang, Hong Zhang, Xiaoli Liang   +3 more
wiley   +1 more source

競泳選手および柔道選手におけるBDNF Val66Met 多型分布の特徴

, 2020
Studies have demonstrated that motivation, aggression, excitation intensity, competitive spirit, and tolerance to psychological stress are included in major psychological factors affecting the performance of athletes.
浅井, 泰詞
core  

The impact of exercise on cognitive function and brain health across the lifespan: A systematic review

Ibrain, EarlyView.
This systematic review of 37 studies demonstrates that aerobic, resistance, and combined exercise enhance cognitive function and brain health across all ages. Exercise promotes neuroplasticity, upregulates brain‐derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF), and mitigates age‐related cognitive decline, establishing ...
Issam AbuQeis, Abeer Teeti, Amro Titi
wiley   +1 more source

Postnatal BDNF-mediated cerebellar granule cell development is impaired in a mouse model of Niemann-Pick type C1 disease

, 2021
Niemann-Pick type C1 disease (NPCD) is a lysosomal storage disorder due to mutations in NPC1, a lysosomal protein related to the Sonic Hedgehog (Shh) receptor and involved in the intracellular trafficking of cholesterol.
Jessica Tiberi, Sonia Canterini, Maria Teresa Fiorenza, Serena Camuso, Alessandro Rava, Piergiorgio La Rosa   +5 more
core  

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

Molecular implications of prolonged aggression experience: Th, Dat1, Snca and Bdnf gene expression in the ventral tegmental area of the victorious male mice

, 2008
Th, Dat1, Snca and Bdnf were the genes whose mRNA levels in the ventral tegmental area of the midbrain were measured in male mice that were victorious in 20 daily agonistic interactions and in a group of such victorious mice that had later not been ...
I. L. Kovalenko, Irina L. Kovalenko, U. A. Boyarskikh, M. L. Filipenko, Ul'yana A. Boyarskikh, N. N. Kudryavtseva, N. P. Bondar, Maxim L. Filipenko, Natalia P. Bondar, Natalia N. Kudryavtseva   +9 more
core  

BDNF variants may modulate long-term visual memory performance in a healthy cohort

, 2017
Brain-derived neurotrophic factor (BDNF) is involved in numerous cognitive functions including learning and memory. BDNF plays an important role in synaptic plasticity in humans and rats with BDNF shown to be essential for the formation of long-term ...
Nesli Avgan, Omar Ibrahim, Griffiths, Lyn, Shum, David, Griffiths, Lyn R, Sutherland, Heidi G., Griffiths, Lyn R., Spriggens, Lauren K, Lauren Spriggens, Spriggens, Lauren, Sutherland, Heidi G, Lyn Griffiths, David Shum, Shum, David HK, Avgan, Nesli, Ibrahim, Omar, Yu, Chieh, Claire Bellis, Heidi Sutherland, Chieh Yu, Larisa Haupt, Haupt, Larisa M, Bellis, Claire, Haupt, Larisa M., Sutherland, Heidi   +24 more
core   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

Interdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi, Min Chen, Yisheng Chen, MengYao Li, Jiale Ma, Zuozhen Yin, Li Wu, YangBao Miao, Zemin Ou, Ke Wu, Zhijie Xu, Lizhi Li, Shaocong Zhao, Shiwei He, Bin Huang, Guanwen He, Guanghui Wu, John H. Zhang, Liang Shi   +18 more
wiley   +1 more source