Low-Molecular Weight BDNF Mimetic, Dimeric Dipeptide GSB-106, Reverses Depressive Symptoms in Mouse Chronic Social Defeat Stress [PDF]
Biomolecules, 2021 A mimetic of the BDNF loop 4, bis (N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide, named GSB-106, was designed and synthesized in our scientific group. The compound activated TrkB, MAPK/ERK, PI3K/AKT, and PLCγ in in vitro experiments.
Tatiana A Gudasheva +2 more
exaly +10 more sources
The mimetic of the brain neurotrophic factor GSB-106 has neuroprotective and neuroregenerative effects in experimental ischemic stroke [PDF]
Фармакокинетика и Фармакодинамика, 2022 Background. A dimeric dipeptide mimetic of the brain-derived neurotrophic factor loop 4, bis(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide (GSB-106), which activates TrkB, PI3K/AKT, MAPK/ERK and PLC-γ1 was created at the V. V.
P. Yu. Povarnina +3 more
doaj +15 more sources
Analysis of Antidepressant-like Effects and Action Mechanisms of GSB-106, a Small Molecule, Affecting the TrkB Signaling [PDF]
International Journal of Molecular Sciences, 2021 Induction of BDNF-TrkB signaling is associated with the action mechanisms of conventional and fast-acting antidepressants. GSB-106, developed as a small dimeric dipeptide mimetic of BDNF, was previously shown to produce antidepressant-like effects in the
Yulia V Vakhitova +2 more
exaly +6 more sources
Evaluation of allergenic properties and immunotoxicity of dipeptide mimetic of brain-derived neurotrophic factor GSB-106 [PDF]
Фармакокинетика и Фармакодинамика, 2020 . The study of allergenic properties and immunotoxic effects of the ready-to-use drug form of GSB-106 was carried out. The study of allergenic properties and immunotoxicity of GSB-106 was performed on male albino guinea pigs weighing 250-300 g and on ...
L. P. Kovalenko +4 more
doaj +6 more sources
Study of the interaction of the GSB-106 BDNF neurotrophin dipeptide mimetic with the TrkB tyrosine kinase receptor using surface plasmon resonance technology [PDF]
Фармакокинетика и Фармакодинамика, 2023 The interaction of the neurotrophin BDNF dipeptide mimetic, compound GSB-106, with the tyrosine kinase TrkB receptor specific for the fullsized neurotrophin was studied using surface plasmon resonance.
A. V. Tarasiuk +4 more
doaj +8 more sources
Pharmacokinetics of dipeptide mimetic BDNF GSB-106 in rats [PDF]
Фармакокинетика и Фармакодинамика, 2019 Pharmacokinetics of the GSB-106 in variety of administration ways in rats was studied. After single oral administration the test substance was determined for 4 h in the blood plasma. Half-life was 0.65 h.
V. P. Zherdev +7 more
doaj +6 more sources
Antidepressant-like activity of the dipeptide mimetic of brain-derived neurotrophic factor GSB-106 in Porsolt test after intraperitoneal sub-chronically and chronically treatment in mice [PDF]
Фармакокинетика и Фармакодинамика, 2020 The present work was to study the GSB-106 effect on the immobility behavior of mice Balb/c in the Porsolt test. GSB-106 was administered sub-chronically and chronically intraperitoneal in dose 1 mg/kg.
A. V. Tallerova +4 more
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The study of the acute and chronic toxicity dipeptide mimetic of brain-derived neurotrophic factor GSB-106 finished dosage form [PDF]
Фармакокинетика и Фармакодинамика, 2019 Resume. The study of acute and chronic toxicity of the finished dosage form (SFF) GSB-106, the active substance of which is the substituted dimeric peptide, hexamethylenediamine bis (N-monosuccinyl-L-seryl-L-lysine), which has antidepressant and ...
S. V. Alekseeva +9 more
doaj +6 more sources
Cytoprotective properties of the nerve growth factor and brain derived neurotrophic factor dipeptidic mimetics, GK-2 AND GSB-106, in the model of oxidative stress in paramecium caudatum [PDF]
Фармакокинетика и Фармакодинамика, 2018 Resume. Actuality. Dimeric dipeptide mimics of the nerve growth factor ( NGF) and brain derived neurotrophic factor (BDNF), respectively GK-2 and GSB-106, were created in the V.V. Zakusov Institute of pharmacology.
O. V. Karpukhina +4 more
doaj +6 more sources
Synthesis and the antidepressant-like activity investigation of bis-(N-monosuccinyl-D-seryl-D-lysine) hexamethylenediamide, the DD-enantiomer of the BDNF dipeptide mimetic, compound GSB-106 [PDF]
Фармакокинетика и ФармакодинамикаPreviously, based on the β-turn of the fourth loop of the brain-derived neurotrophic factor, we obtained GSB-106 (bis-(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide), that has pronounced neuroprotective and antidepressant activities in doses of 0.
N. M. Sazonova +7 more
doaj +4 more sources