Results 41 to 50 of about 919 (130)

Highly Efficient Blue Electroluminescence Based on Pyrene‐Imidazole With Donor–π–Acceptor Molecular Structure

Aggregate, Volume 7, Issue 2, February 2026.
The meta‐linked D–π–A emitter m‐PyI‐PBO adopts a twisted V‐shaped geometry that balances LE/CT states and enables efficient exciton utilization, yielding 9.52% EQE with 3.36% roll‐off in a nondoped blue OLED and 13.22% EQE with 79.72% exciton utilization efficiency in a doped deep‐blue device.
Yulong Liu, Ling Gao, Xianming Zhang, Wenjun Liu, Peng Jiang, Anchen Wang, Zishi Wang, Ying Fu   +7 more
wiley   +1 more source

Mimetics of brain-derived neurotrophic factor loops 1 and 4 are active in a model of ischemic stroke in rats

Drug Design, Development and Therapy, 2016
Tatyana A Gudasheva,1 Polina Povarnina,1 Ilya O Logvinov,2 Tatyana A Antipova,2 Sergey B Seredenin3 1Department of Medicinal Chemistry, 2Department of Neuroprotective Pharmacology, 3Department of Pharmacogenetics, VV Zakusov Institute of Pharmacology ...
Gudasheva TA, Povarnina P, Logvinov IO, Antipova TA, Seredenin SB   +4 more
doaj  

Enhancing Photocatalytic CO2 Reduction via Robust Polymer Fragment–Single‐Walled Carbon Nanotube Heterojunction Engineering

Advanced Energy Materials, Volume 15, Issue 45, December 2, 2025.
This work presents a polymer fragmentation procedure to construct SWNT/CNF heterojunction. The SWNT/CNF hybrid exhibits exceptional CO2 photoreduction performance with selective CH4 production. The enhanced activity originates from enhanced CO2 adsorption, optimized dynamics, and robust interfacial coupling between SWNT and CNF, which establish Ohmic ...
Xiaolong Zhao, Ying Tao, Mingyu Xia, Kee Wah Leong, Yingguang Zhang, Shijing Luo, Weicheng Chen, Mahmoud Samy, Xiaoping Yi, Wending Pan, Guisheng Li, Dennis Y. C. Leung   +11 more
wiley   +1 more source

Strategic Design of Aptamer‐Guided Aggregation‐Induced Emission Nanoparticles for Targeted Photodynamic Therapy in Breast Cancer

Advanced Science, Volume 12, Issue 43, November 20, 2025.
This study presents MF3Ec‐TBPP nanoparticles for targeted photodynamic therapy of Luminal A breast cancer. These nanoparticles combine an AIE‐based photosensitizer with an aptamer. Tests show they effectively inhibit tumor growth while protecting healthy tissue via aggregation and dipalmitoylphosphatidylcholine, indicating potential for improved ...
Charlie C. H. Ma, Qingqing Liu, Yue Sui, Wutong Du, Kristy W. K. Lam, Jacky W. Y. Lam, Chao Li, Tengteng Chen, Jianwei Sun, Nuomin Li, Ryan T. K. Kwok, Jianping Chen, Feiyi Sun, Ben Zhong Tang   +13 more
wiley   +1 more source

Improving somatic health for outpatients with severe mental illness: the development of an intervention [PDF]

, 2012
Objective: Patients with severe mental illness (SMI) suffer from more somatic illness than the general population. Possible causes are side effects of neuropsychiatric medication, genetic vulnerability, insufficient health care and lifestyle.
Loonen, Antonius, van Hasselt, F.
core   +1 more source

Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting KMT2A::AFF1 with Enhanced Extrahepatic Delivery

Advanced Healthcare Materials, Volume 14, Issue 27, October 20, 2025.
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah, Remant KC, Amarnath Praphakar Rajendran, Saba Abbasi Dezfouli, Cezary Kucharski, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Olaf Heidenreich, Hasan Uludağ   +9 more
wiley   +1 more source

Tuning Charge‐Separated State Lifetimes in Perovskite Nanocrystal‐Perylenediimide Hybrids

Advanced Optical Materials, Volume 13, Issue 28, October 2, 2025.
Functional perylenediimides with varied spacer lengths surface engineer CsPbBr₃ perovskite nanocrystals, yielding hybrid materials with new properties. Time‐resolved techniques reveal photoinduced charge separation from perovskite nanocrystals to perylenediimides, with microsecond‐lived charge carriers. Spacer length modulates charge carrier lifetimes,
Alejandro Cortés‐Villena, José Garcés‐Garcés, Alejandro Cadranel, Alberto García‐Ros, Ángela Sastre‐Santos, Fernando Fernández‐Lázaro, Julia Pérez‐Prieto, Dirk M. Guldi, Raquel E. Galian   +8 more
wiley   +1 more source

Triple‐Functional CuxAu61‐x Nanoclusters with NIR‐II Photoluminescence, Photothermal and Photodynamic Properties and Their Bio‐Application

Advanced Science, Volume 12, Issue 39, October 20, 2025.
A new CuxAu61‐x nanocluster was synthesized by doping Cu atoms into the Au60 nanocluster, and “one stone two birds” was achieved, in which both the NIR‐II emission and ROS generation of the CuxAu61‐x nanocluster were significantly enhanced. Considering its photothermal effect, a CuxAu61‐x@SiO2‐FA nanoplatform was constructed for NIR‐II luminescence ...
Tingting Xu, Jie Kong, Yu Chen, Wenxue Cui, Yucheng Fang, Wei Zhang, Mohan Wang, Meng Zhou, Yingwei Li, Rongchao Jin, Yongbo Song   +10 more
wiley   +1 more source

PRECISION MEDICINE AND GRAFT-INDUCED DYSKINESIA (GID) : INVESTIGATING THE CURIOUS SIDE EFFECT OF DOPAMINE NEURON TRANSPLANTATION IN THE rs6265 BDNF (MET/MET) PARKINSONIAN BRAIN [PDF]

Thesis (Ph.D.)--Michigan State University. Pharmacology and Toxicology - Doctor of Philosophy, 2025While dopamine (DA) neuron transplantation is a promising alternative therapy to the current pharmacological agents (e.g., levodopa) prescribed for ...
Szarowicz, Carlye Anne
core   +2 more sources

Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GK-2 in rats. Part 2. Kinetics of distribution in organs and tissues [PDF]

Relevance. To introduce the GK-2 compound into clinical practice, it is necessary to conduct a preclinical study of its pharmacokinetics, in particular, the distribution of the studied drug in organs and tissues.
A. A. Litvin, G. B. Kolyvanov, O. G. Gribakina, O. Yu. Kravtsova, P. O. Bochkov, P. Yu. Povarnina, V. P. Zherdev   +6 more
core   +2 more sources