Screening study of nerve growth factor's and brain-derived neurotrophic factor's mimetics effects at the experimental depression model [PDF]
Фармакокинетика и Фармакодинамика, 2020 At the Zakusov Institute of Pharmacology designed and synthesized dimeric dipeptide mimetics of the 1st (GK-6) and 4th (GK-2) nerve growth factor loops, 1st (GSB-214), 2nd (GTS-201) and 4th (GSB -106, GSB-106Ac) brain-derived neurotrophic factor loops ...
A. G. Mezhlumyan +5 more
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A study of neuroprotective effect stereospecificity of dipeptide mimetic of the Brain-derived neurotrophic factor GSB-106 on the model oxidative stress in the culture hippocampal cell line HT-22 [PDF]
Фармакокинетика и Фармакодинамика, 2017 In the present work, the neuroprotective effect stereospecificity of dimeric dipeptide mimetic of the 4th loop of BDNF-GSB-106 is studied. Activity of its diastereomers GT-106DL (hexamethylenediamide bis-monosuccinyl-D-seryl-L-lysine) and GT-106LD ...
I. O. Logvinov +3 more
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Comparison of neuroprotective properties of the dipeptide mimetics of the 1st, 2nd and 4th loops of the brain-derived neurotrophic factor on the model oxidative stress in vitro [PDF]
Фармакокинетика и Фармакодинамика, 2019 Resume. The purpose of this study was to compare neuroprotective properties of the dimeric dipeptide mimetics of the 1st, 2nd and 4th Loops of BDNF - GSB-214 (heptamethylenediamide bis-monosuccinyl-methionyl-serine), GTS-201 (hexamethylenediamide bis ...
I. O. Logvinov +5 more
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Antidepressant-like Effects of BDNF and NGF Individual Loop Dipeptide Mimetics Depend on the Signal Transmission Patterns Associated with Trk [PDF]
Pharmaceuticals, 2022 Neurotrophins are considered as an attractive target for the development of antidepressants with a novel mechanism of action. Previously, the dimeric dipeptide mimetics of individual loops of nerve growth factor, NGF (GK-6, loop 1; GK-2, loop 4) and ...
Armen G. Mezhlumyan +6 more
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Scientific Reports, 2021 Brain-derived neurotrophic factor (BDNF) is involved in the regulation of neuronal cell growth, differentiation, neuroprotection and synaptic plasticity.
L. F. Zainullina +4 more
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Dimeric dipeptide mimetics of BDNF loop 4 are potential antidepressants with novel mechanisms of action [PDF]
Фармакокинетика и ФармакодинамикаThis review covers original research focused on the design, synthesis, and pharmacological evaluation of an innovative dimeric dipeptide mimetic of brain-derived neurotrophic factor (BDNF) loop 4 bis-(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide
T. A. Gudasheva +4 more
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CNS & Neurological Disorders - Drug Targets, 2021 Background: A dimeric dipeptide mimetic of the BDNF loop 4, bis(N-monosuccinyl- L-seryl-L-lysine) hexamethylenediamide (GSB-106) activates TrkB, PI3K/AKT, MAPK/ ERK, and PLC-γ1, and was created at the V.V.
Dmitry M. Nikiforov +6 more
core +3 more sources
Molecular Design of Highly Efficient Heavy-Atom-Free Near-Infrared Cyanine Photosensitizers for Fluorescence Image-Guided Photodynamic Therapy of Solid Tumors. [PDF]
Adv Healthc MaterHighly efficient heavy‐atom‐free NIR photosensitizers based on a heptamethine cyanine platform were developed for image‐guided photodynamic therapy. Both in vitro and in vivo results revealed that the R820‐3 photosensitizer with a highly twisted molecular structure exhibited potential for NIR fluorescence image‐guided photodynamic cancer therapy ...
Nguyen VN +9 more
europepmc +2 more sources
Study of the efficiency of using disinfectants «Adalux» to provide paper material with bactericidal properties [PDF]
Annals of Mechnikov's Institute, 2020 Introduction. The issue of environmental management and protection of the environment from pollution are of paramount importance. Today, there is a big problem associated with the accumulation of polymer waste, which catastrophically pollutes the planet.
I Zinchenko +4 more
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Assessing the problem of excitation light scattering in high-viscosity jets used in serial crystallography sample delivery. [PDF]
J Appl CrystallogrWe experimentally demonstrate that the scattering‐induced decrease in light intensity experienced by a crystal embedded in a high‐viscosity jet is very limited in materials such as lipidic cubic phase or hydroxyethyl cellulose, and therefore cannot justify the use of pump energies exceeding the linear excitation regime under realistic experimental ...
Niziński S +5 more
europepmc +2 more sources