Results 261 to 270 of about 122,805 (310)

NGF and BDNF in pediatrics syndromes

Neuroscience & Biobehavioral Reviews, 2023
Neurotrophins (NTs) as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) play multiple roles in different settings including neuronal development, function and survival in both the peripheral and the central nervous systems from early stages.
Ferraguti, Giampiero, Terracina, Sergio, Micangeli, Ginevra, Lucarelli, Marco, Tarani, Luigi, Ceccanti, Mauro, Spaziani, Matteo, D'Orazi, Valerio, Petrella, Carla, Fiore, Marco   +9 more
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Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

Nature Neuroscience, 2008
Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival. Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by ...
Matsumoto, T., Rauskolb, S., Polack, M., Klose, J., Kolbeck, R., Korte, M., Barde, Y. -A.   +6 more
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Steroid hormones and BDNF

Neuroscience, 2013
Brain-derived neurotrophic factor (BDNF) is a neurotrophin abundantly expressed in several areas of the central nervous system (CNS) and is known to induce a lasting potentiation of synaptic efficacy, to enhance specific learning and memory processes.
Pluchino N, Russo M, Santoro AN, LITTA, PIETRO SALVATORE, Cela V, Genazzani AR   +5 more
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Association of circulating BDNF levels with BDNF rs6265 polymorphism in schizophrenia

Behavioural Brain Research, 2020
Schizophrenia is a severe neuropsychiatric disorder affecting 1% of the world population. Disturbances in neuronal development and synaptic connections are important factors in the pathogenesis of schizophrenia. Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays a critical role in the development of neurons.
Pvsn Kiran, Kumar, Prasenjit, Mitra, Raghumoy, Ghosh, Shailja, Sharma, Naresh, Nebhinani, Praveen, Sharma   +5 more
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A role for BDNF in mechanosensation

Nature Neuroscience, 1998
Brain-derived neurotrophic factor (BDNF) is a survival factor for certain sensory neurons during development. Using electrophysiology in BDNF-deficient mice, we show here that slowly adapting mechanoreceptors (SAM), but not other types of cutaneous afferents, require BDNF in postnatal life for normal mechanotransduction.
P, Carroll, G R, Lewin, M, Koltzenburg, K V, Toyka, H, Thoenen   +4 more
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BDNF dependence in neuroblastoma

Journal of Neuroscience Research, 2001
AbstractNeuroblastomas are heterogeneous tumors arising from sympathetic precursors in the neural crest. Growth factor stimulation of neuroblastomas promote diverse biological responses (mitogenesis, differentiation, cell death) depending on the particular tumor studied.
X, Feng, H, Jiang, J C, Baik, C, Edgar, F F, Eide   +4 more
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BDNF During Withdrawal

2017
Among the adaptations observed following drugs of abuse consumption, BDNF levels are widely altered in both brain and periphery. In this chapter, we first reviewed these adaptations in preclinical studies, in both juveniles and adult animals. A particular focus was made on protracted withdrawal as incubation is often associated with an increase in ...
H, Geoffroy, F, Noble
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BDNF as a pain modulator

Progress in Neurobiology, 2008
At least some neurotrophins may be powerful modulators of synapses, thereby influencing short- and long-term synaptic efficiency. BDNF acts at central synapses in pain pathways both at spinal and supraspinal levels. Neuronal synthesis, subcellular storage/co-storage and release of BDNF at these synapses have been characterized on anatomical and ...
A. Merighi, C. Salio, GHIRRI, Alessia, L. Lossi, F. Ferrini, BETELLI, CHIARA, BARDONI, Rita   +6 more
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Bioinformatics Approach to BDNF and BDNF-Related Disorders

Current Neuropharmacology, 2011
Context: Currently, the keyword 'BDNF' retrieves 7388 publications in Pubmed, which point to many directions.Objective: This paper aims to uncover patterns that are hidden under this huge mass of studies and then to review the most prominent sub-topics in 'BDNF and mental health'.Method: Several semi-automatic tools employed, in order to present: 1.
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Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities

Nature Neuroscience, 2000
To directly compare biological activities of the neurotrophins NT4 and BDNF in vivo, we replaced the BDNF coding sequence with the NT4 sequence in mice (Bdnfnt4-ki). Mice expressing NT4 in place of BDNF were viable, in contrast with BDNF null mutants, which die shortly after birth.
Fan, G., Egles, C., Sun, Y., Minichiello, L., Renger, J., Klein, R., Liu, G., Jaenisch, R.   +7 more
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