Results 251 to 260 of about 184,218 (302)

Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

Nature Neuroscience, 2008
Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival. Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by ...
Matsumoto, T., Rauskolb, S., Polack, M., Klose, J., Kolbeck, R., Korte, M., Barde, Y. -A.   +6 more
openaire   +3 more sources

BDNF copycats

Nature Reviews Drug Discovery, 2010
exaly   +2 more sources

Association of circulating BDNF levels with BDNF rs6265 polymorphism in schizophrenia

Behavioural Brain Research, 2020
Schizophrenia is a severe neuropsychiatric disorder affecting 1% of the world population. Disturbances in neuronal development and synaptic connections are important factors in the pathogenesis of schizophrenia. Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays a critical role in the development of neurons.
Pvsn Kiran, Kumar, Prasenjit, Mitra, Raghumoy, Ghosh, Shailja, Sharma, Naresh, Nebhinani, Praveen, Sharma   +5 more
openaire   +2 more sources

BDNF During Withdrawal

2017
Among the adaptations observed following drugs of abuse consumption, BDNF levels are widely altered in both brain and periphery. In this chapter, we first reviewed these adaptations in preclinical studies, in both juveniles and adult animals. A particular focus was made on protracted withdrawal as incubation is often associated with an increase in ...
H, Geoffroy, F, Noble
openaire   +2 more sources

Steroid hormones and BDNF

Neuroscience, 2013
Brain-derived neurotrophic factor (BDNF) is a neurotrophin abundantly expressed in several areas of the central nervous system (CNS) and is known to induce a lasting potentiation of synaptic efficacy, to enhance specific learning and memory processes.
Pluchino N, Russo M, Santoro AN, LITTA, PIETRO SALVATORE, Cela V, Genazzani AR   +5 more
openaire   +2 more sources

BDNF dependence in neuroblastoma

Journal of Neuroscience Research, 2001
AbstractNeuroblastomas are heterogeneous tumors arising from sympathetic precursors in the neural crest. Growth factor stimulation of neuroblastomas promote diverse biological responses (mitogenesis, differentiation, cell death) depending on the particular tumor studied.
X, Feng, H, Jiang, J C, Baik, C, Edgar, F F, Eide   +4 more
openaire   +2 more sources