Results 61 to 70 of about 72,789 (286)
Probing embedded star clusters in the HII complex NGC 6357 with VVV [PDF]
, 2014 NGC 6357 is an active star-forming region located in the Sagittarius arm displaying several star clusters, which makes it a very interesting target to investigate star formation and early cluster evolution.
Bica, E. +3 more
core +3 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Applied Mathematics-A Journal of Chinese UniversitiesIn this paper, we focus on the BDS test, which is a nonparametric test of independence. Specifically, the null hypothesis $H_{0}$ of it is that $\{u_{t}\}$ is i.i.d. (independent and identically distributed), where $\{u_{t}\}$ is a random sequence. The BDS test is widely used in economics and finance, but it has a weakness that cannot be ignored: over ...
Luo, Wen-ya +3 more
openaire +2 more sources
A discontinuity in the low-mass IMF - the case of high multiplicity
, 2008 The empirical binary properties of brown dwarfs (BDs) differ from those of normal stars suggesting BDs form a separate population. Recent work by Thies & Kroupa revealed a discontinuity of the initial mass function (IMF) in the very-low-mass star regime ...
Adams +51 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Detection of brown dwarf-like objects in the core of NGC3603
, 2011 We use near-infrared data obtained with the Wide Field Camera 3 (WFC3) on the Hubble Space Telescope to identify objects having the colors of brown dwarfs (BDs) in the field of the massive galactic cluster NGC 3603.
Abhijit Saha +83 more
core +1 more source
Jets from young stars and brown dwarfs [PDF]
, 2014 The protostellar outflow mechanism operates for a significant fraction of the pre-main sequence phase of a solar mass star and is thought to have a key role in star and perhaps even planet formation.
Whelan, E. T.
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Metal-rich T-dwarfs in the Hyades cluster
, 2008 We present the results of a search for brown dwarfs (BDs) and very low mass (VLM) stars in the 625 Myr-old, metal-rich ([Fe/H]=0.14) Hyades cluster. We performed a deep (I=23, z=22.5) photometric survey over 16 deg$^2$ around the cluster center.
Eric Stempels +3 more
core +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source