Results 71 to 80 of about 77,848 (283)

A Subset-Reduced Method for FDE ARAIM of Tightly-Coupled GNSS/INS

open access: yesSensors, 2019
The advanced receiver autonomous integrity monitoring (advanced RAIM, ARAIM) is the next generation of RAIM which is widely used in civil aviation. However, the current ARAIM needs to evaluate hundreds of subsets, which results in huge computational ...
Weichuan Pan   +3 more
doaj   +1 more source

Likelihood-Based Inference for Discretely Observed Birth-Death-Shift Processes, with Applications to Evolution of Mobile Genetic Elements

open access: yes, 2014
Continuous-time birth-death-shift (BDS) processes are frequently used in stochastic modeling, with many applications in ecology and epidemiology. In particular, such processes can model evolutionary dynamics of transposable elements - important genetic ...
Biémont   +19 more
core   +1 more source

The Return of Business Creation [PDF]

open access: yes, 2013
Freshly released government data show that new business formation rebounded in 2011, after four years of decline, from the depths of the Great Recession.
Dane Stangler   +2 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Performance Evaluation of Real-Time Precise Point Positioning with Both BDS-3 and BDS-2 Observations

open access: yesSensors, 2020
For time-critical precise applications, one popular technology is the real-time precise point positioning (PPP). In recent years, there has been a rapid development in the BeiDou Navigation Satellite System (BDS), and the constellation of global BDS (BDS-
Lin Pan   +7 more
doaj   +1 more source

Detection of brown dwarf-like objects in the core of NGC3603

open access: yes, 2011
We use near-infrared data obtained with the Wide Field Camera 3 (WFC3) on the Hubble Space Telescope to identify objects having the colors of brown dwarfs (BDs) in the field of the massive galactic cluster NGC 3603.
Abhijit Saha   +83 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Metal-rich T-dwarfs in the Hyades cluster

open access: yes, 2008
We present the results of a search for brown dwarfs (BDs) and very low mass (VLM) stars in the 625 Myr-old, metal-rich ([Fe/H]=0.14) Hyades cluster. We performed a deep (I=23, z=22.5) photometric survey over 16 deg$^2$ around the cluster center.
Eric Stempels   +3 more
core   +2 more sources

Jets from young stars and brown dwarfs [PDF]

open access: yes, 2014
The protostellar outflow mechanism operates for a significant fraction of the pre-main sequence phase of a solar mass star and is thought to have a key role in star and perhaps even planet formation.
Whelan, E. T.
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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