Results 111 to 120 of about 1,142,001 (295)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Long-term Multiwavelength Observations of RX J0440.9+4431: Unraveling the Mysteries of the Missing X-Ray Outburst and the Unique Giant Outburst

open access: yesThe Astrophysical Journal
RX J0440.9+4431 is a Be/X-ray binary. Since its discovery, the H α equivalent width (EW) of this source has exhibited three peaks, which correspond to different X-ray activities: three type I X-ray outbursts, no outburst, and a combined type I + type II ...
Xiukun Li   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Challenging Classical Paradigms: Recurrent Nova M31N 2017-01e, a BeWD System in M31?

open access: yesThe Astrophysical Journal
M31N 2017-01e is the second-fastest recurrent nova known, with a recurrence period of 2.5 yr in the Andromeda galaxy (M31). This system exhibits a unique combination of properties: a low outburst amplitude (∼3 mag), starkly contrasting with known ...
Shatakshi Chamoli   +5 more
doaj   +1 more source

Lithium and the evolution of intermediate-mass T Tauri and Herbig stars

open access: yesAstronomy & Astrophysics
Context. Interior models predict that stellar envelopes change from convective to radiative during the pre-main-sequence (pre-MS) evolution of intermediate-mass stars.
Mendigutía I.   +11 more
doaj   +1 more source

On the Frequency of Field Galactic Be Stars

open access: yes, 2005
Since Be stars belong to the high velocity tail of a single B star velocity distribution, the appearance of the Be phenomenon must be independent of the stellar mass.
Fremat, Yves, Zorec, Juan
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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