Results 121 to 130 of about 1,142,001 (295)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The Astrophysical Journal LettersWe present observations of the gamma-ray binary PSR B1259-63/LS 2883 with the Atacama Large Millimeter/submillimeter Array (ALMA) at Band 3 (97 GHz), Band 6 (233 GHz), and Band 7 (343 GHz).
Yutaka Fujita +5 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Astronomy & AstrophysicsThe Galactic Be star binary MWC 656 was long considered the only known Be star+black hole (BH) system, making it a critical benchmark for models of massive binary evolution and for the expected X-ray emission of Be+BH binaries.
Müller-Horn Johanna +13 more
doaj +1 more source
Magnetic fields of Herbig Ae/Be stars
EPJ Web of Conferences, 2014 We report on the status of our spectropolarimetric studies of Herbig Ae/Be stars carried out during the last years. The magnetic field geometries of these stars, investigated with spectropolarimetric time series, can likely be described by centred ...
Hubrig S. +7 more
doaj +1 more source
Ultraviolet properties of IRAS-selected Be stars [PDF]
New IUE observations were obtained of 35 Be stars from a list of stars which show excess infrared fluxes in IRAS data. The IRAS-selected Be stars show larger C IV and Si IV equivalent widths than other Be stars.
Bjorkman, Karen S., Snow, Theodore P.
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Be star o Cas is indeed the primary of a triple system
Astronomy & AstrophysicsAnalysis of radial velocities of two narrow absorption components in the Mg II 4481 Å line demonstrated that the secondary of the Be star o Cas is indeed a close binary system composed of two B7 stars orbiting each other with a period of 11.″6604 11
Harmanec P. +5 more
doaj +1 more source