Results 141 to 150 of about 34,754,919 (296)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Magnetic field, rotation, and binarity of the first magnetic B[e] star, IRAS 17449+2320
Astronomy & AstrophysicsContext. IRAS 17449+2320 is the first identified magnetic B[e] star. It belongs to a subgroup of peculiar hot B-type stars, called FS CMa stars. All these objects present the B[e] phenomenon, i.e., permitted and forbidden emission lines, and infrared ...
Bermejo Lozano I. +3 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Double Stars, Double Disks: Discovering the Young Companion of Herbig Be Star MWC 340
The Astrophysical JournalWe present the discovery of a young, close-in companion to the early B-type Herbig Be star MWC 340 (V1685 Cyg), a rare system known to host a protoplanetary disk.
Noura Ibrahim +10 more
doaj +1 more source
Exploring the variability of young stars with Gaia DR3 light curves
Astronomy & AstrophysicsContext. Photometric variability is a defining characteristic of young stellar objects (YSOs) that can be traced back to a range of physical processes that occur at different stages in the formation and early evolution of young stars. The Gaia third Data
Mas C. +7 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source