Results 141 to 150 of about 700,478 (387)
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Curvature and torsion in growing actin networks
, 2007 Intracellular pathogens such as Listeria monocytogenes and Rickettsia rickettsii move within a host cell by polymerizing a comet-tail of actin fibers that ultimately pushes the cell forward.
Daniel A Fletcher +2 more
core +1 more source
, 1993 La publicación describe los aspectos geográficos, socioeconómicos y patrimoniales más significativos que presenta el municipio orensano de Beade, que ocupa una posición central dentro de la conocida comarca vitivinícola del Ribeiro y cuyo territorio, en el que predominan los viñedos, presenta unas tierras de valle drenadas por el río Avia, que bordea ...
openaire +1 more source
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
Characterisation of the behaviour of welded aluminium structures under dynamic loading
EPJ Web of Conferences, 2018 The presence and quality of welds in metallic structures has the ability to influence their likelihood of failure under dynamic loading. This investigation focused on characterising the behaviour of a welded aluminium structure.
Bornstein Huon +5 more
doaj +1 more source
Effect of algal density in bead, bead size and bead concentrations on wastewater nutrient removal
African Journal of Biotechnology, 2007 Laboratory experiments were performed to study nitrogen and phosphorus uptake by the unicellular green microalga Chlorella vulgaris immobilized in calcium alginate beads. Different cell stockings inbeads, different bead sizes and different algal bead concentrations in wastewaters were tested.
openaire +4 more sources
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source